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פותח על ידי קלירמאש פתרונות בע"מ -
FABP4 gene has a very large effect on feed efficiency in lactating Israeli Holstein cows - Abstract
Year:
2019
Source of publication :
Physiological Genomics
Authors :
אגמון, רותם
;
.
בן-מאיר, יהושב
;
.
כהן-צינדר, מירי
;
.
מירון, יהושע
;
.
שבתאי, אריאל
;
.
שור-שמעוני, עינב
;
.
Volume :
51
Co-Authors:

 Lipkin, E., Department of Genetics, Hebrew University of JerusalemJerusalem, Israel;  Asher, A., Northern R&D, MIGAL, Galilee Technology Center, Israel;

Facilitators :
From page:
481
To page:
487
(
Total pages:
7
)
Abstract:

Improving feed efficiency (FE) is a major goal for the livestock industry. Previously, we have identified 48 SNP markers distributed over 32 genes significantly associated with residual feed intake (RFI) in Israeli Holstein male calves, the most significant of which are located in the bovine FABP4 gene. In the present study, we tested associations of eight of the FABP4 markers with RFI and feed conversion ratio (FCR), along with milk composition and feeding behavioral traits, in 114 lactating Israeli Holstein cows. Large allele effects were found, along with large contributions of FABP4 markers to the phenotypic variation [mean contribution of all significant markers (P < 0.05), 15.4 and 12.0% for RFI and FCR, respectively] and genotypic variation [means of all significant markers (P < 0.05), 75.7 and 32.4% in RFI and FCR, respectively]. However, the association of all significant FABP4 markers with FE and milk content traits was found in opposite directions, such that improved FE was accompanied by decreased milk content. Hence, before inclusion in breeding programs, the gain in FE must be economically balanced with the loss in milk contents. On the other hand, these findings imply that in any current improvement program concentrated on milk traits alone, without taking into account the effect on FE, the progress in milk composition is probably accompanied by deterioration of FE. These results, if confirmed in other populations and breeds, set FABP4 as a prime candidate in any marker-assisted selection program targeting FE as a whole and RFI in particular.

Note:
Related Files :
FABP4 gene
Feed efficiency
Feed efficiency (FE)
Genotypic variation
Holstein
עוד תגיות
תוכן קשור
More details
DOI :
10.1152/physiolgenomics.00051.2019
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
תקציר
;
.
Language:
אנגלית
Editors' remarks:
ID:
44006
Last updated date:
02/03/2022 17:27
Creation date:
02/10/2019 11:35
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Scientific Publication
FABP4 gene has a very large effect on feed efficiency in lactating Israeli Holstein cows - Abstract
51

 Lipkin, E., Department of Genetics, Hebrew University of JerusalemJerusalem, Israel;  Asher, A., Northern R&D, MIGAL, Galilee Technology Center, Israel;

FABP4 gene has a very large effect on feed efficiency in lactating Israeli Holstein cows

Improving feed efficiency (FE) is a major goal for the livestock industry. Previously, we have identified 48 SNP markers distributed over 32 genes significantly associated with residual feed intake (RFI) in Israeli Holstein male calves, the most significant of which are located in the bovine FABP4 gene. In the present study, we tested associations of eight of the FABP4 markers with RFI and feed conversion ratio (FCR), along with milk composition and feeding behavioral traits, in 114 lactating Israeli Holstein cows. Large allele effects were found, along with large contributions of FABP4 markers to the phenotypic variation [mean contribution of all significant markers (P < 0.05), 15.4 and 12.0% for RFI and FCR, respectively] and genotypic variation [means of all significant markers (P < 0.05), 75.7 and 32.4% in RFI and FCR, respectively]. However, the association of all significant FABP4 markers with FE and milk content traits was found in opposite directions, such that improved FE was accompanied by decreased milk content. Hence, before inclusion in breeding programs, the gain in FE must be economically balanced with the loss in milk contents. On the other hand, these findings imply that in any current improvement program concentrated on milk traits alone, without taking into account the effect on FE, the progress in milk composition is probably accompanied by deterioration of FE. These results, if confirmed in other populations and breeds, set FABP4 as a prime candidate in any marker-assisted selection program targeting FE as a whole and RFI in particular.

Scientific Publication
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