Caio Takiya, Shawnee Montgomery, Laman Mamedova, Barry Bradford - Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506, United States

Yishai Levin  -The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 7610001, Israel

Sherry Fleming  -Division of Biology, Kansas State University, Manhattan 66506, United States

This article contains raw and processed data related to research published by Takiya et al. [1]. Literature have shown that treatment with the nonsteroidal anti-inflammatory agent sodium salicylate (SS) during the first days postpartum in dairy cows increased lactation performance [2], and tended to alter glucose metabolism [3]. Yet, the specific effects of systemic SS treatment on the proteome of the adipose tissue (AT) and on the inflammatory process in AT of postpartum cows is unknown. Subcutaneous AT samples were collected at 7 d of lactation from control cows (n = 5) and from cows treated with 2.3 g/L SS (n = 5) via drinking water during the first 7 d of lactation. Protein extraction and liquid chromatography-mass spectrometry were performed to obtain proteomics data. Differential abundance of proteins was determined through MS1 intensity based label-free method. Proteomics analysis generated a novel dataset consisted of 1422 proteins, 80 (5.6%) of which were differentially abundant [fold change ± 1.5, P < 0.05 2-way ANOVA] when comparing control and SS-treated cows. The present dataset of subcutaneous AT proteome from postpartum dairy cows treated with SS can be used as a reference for any research involving nonsteroidal anti-inflammatory agent treatment in dairy cows or in comparative research between species.