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פותח על ידי קלירמאש פתרונות בע"מ -
The Emergence of Insect Odorant Receptor-Based Biosensors
Year:
2020
Source of publication :
Biosensors (Basel)
Authors :
ורניק, ספי
;
.
Volume :
10
Co-Authors:

Bohbot, JD.  Department of Entomology, the Hebrew University of Jerusalem, Rehovot 76100, Israel.

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

The olfactory receptor neurons of insects and vertebrates are gated by odorant receptor (OR) proteins of which several members have been shown to exhibit remarkable sensitivity and selectivity towards volatile organic compounds of significant importance in the fields of medicine, agriculture and public health. Insect ORs offer intrinsic amplification where a single binding event is transduced into a measurable ionic current. Consequently, insect ORs have great potential as biorecognition elements in many sensor configurations. However, integrating these sensing components onto electronic transducers for the development of biosensors has been marginal due to several drawbacks, including their lipophilic nature, signal transduction mechanism and the limited number of known cognate receptor-ligand pairs. We review the current state of research in this emerging field and highlight the use of a group of indole-sensitive ORs (indolORs) from unexpected sources for the development of biosensors.

Note:
Related Files :
Biosensor
Biosensors
indole
Volatile organic compound (VOC)
עוד תגיות
תוכן קשור
More details
DOI :
10.3390/bios10030026
Article number:
0
Affiliations:
Database:
PubMed
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
46986
Last updated date:
02/03/2022 17:27
Creation date:
23/03/2020 17:26
You may also be interested in
Scientific Publication
The Emergence of Insect Odorant Receptor-Based Biosensors
10

Bohbot, JD.  Department of Entomology, the Hebrew University of Jerusalem, Rehovot 76100, Israel.

The Emergence of Insect Odorant Receptor-Based Biosensors

The olfactory receptor neurons of insects and vertebrates are gated by odorant receptor (OR) proteins of which several members have been shown to exhibit remarkable sensitivity and selectivity towards volatile organic compounds of significant importance in the fields of medicine, agriculture and public health. Insect ORs offer intrinsic amplification where a single binding event is transduced into a measurable ionic current. Consequently, insect ORs have great potential as biorecognition elements in many sensor configurations. However, integrating these sensing components onto electronic transducers for the development of biosensors has been marginal due to several drawbacks, including their lipophilic nature, signal transduction mechanism and the limited number of known cognate receptor-ligand pairs. We review the current state of research in this emerging field and highlight the use of a group of indole-sensitive ORs (indolORs) from unexpected sources for the development of biosensors.

Scientific Publication
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