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פותח על ידי קלירמאש פתרונות בע"מ -
Reversible antisense inhibition of Shaker-like Kv1.1 potassium channel expression impairs associative memory in mouse and rat
Year:
1997
Authors :
מאירי, נעם
;
.
Volume :
94
Co-Authors:

Noam Meiri, 
Carla Ghelardini, 
Giuseppina Tesco, 
Nicoletta Galeotti, 
Dennis Dahl, 
Daniel Tomsic, 
Sebastiano Cavallaro, 
Alessandro Quattrone, 
Sergio Capaccioli, 
Alessandro Bartolini,
Daniel L. Alkon

Facilitators :
From page:
4430
To page:
4434
(
Total pages:
5
)
Abstract:

Long-term memory is thought to be subserved by functional remodeling of neuronal circuits. Changes in the weights of existing synapses in networks might depend on voltage-gated potassium currents. We therefore studied the physiological role of potassium channels in memory, concentrating on the Shaker-like Kv1.1, a late rectifying potassium channel that is highly localized within dendrites of hippocampal CA3 pyramidal and dentate gyrus granular cells. Repeated intracerebroventricular injection of antisense oligodeoxyribonucleotide to Kv1.1 reduces expression of its particular intracellular mRNA target, decreases late rectifying K+ current(s) in dentate granule cells, and impairs memory but not other motor or sensory behaviors, in two different learning paradigms, mouse passive avoidance and rat spatial memory. The latter, hippocampal-dependent memory loss occurred in the absence of long-term potentiation changes recorded both from the dentate gyrus or CA1. The specificity of the reversible antisense targeting of mRNA in adult animal brains may avoid irreversible developmental and genetic background effects that accompany transgenic “knockouts”.

Note:
Related Files :
inhibition
Memory
potassium channel
rat
עוד תגיות
תוכן קשור
More details
DOI :
10.1073/pnas.94.9.4430
Article number:
0
Affiliations:
Database:
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
50498
Last updated date:
02/03/2022 17:27
Creation date:
23/09/2020 19:03
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Scientific Publication
Reversible antisense inhibition of Shaker-like Kv1.1 potassium channel expression impairs associative memory in mouse and rat
94

Noam Meiri, 
Carla Ghelardini, 
Giuseppina Tesco, 
Nicoletta Galeotti, 
Dennis Dahl, 
Daniel Tomsic, 
Sebastiano Cavallaro, 
Alessandro Quattrone, 
Sergio Capaccioli, 
Alessandro Bartolini,
Daniel L. Alkon

Reversible antisense inhibition of Shaker-like Kv1.1 potassium channel expression impairs associative memory in mouse and rat

Long-term memory is thought to be subserved by functional remodeling of neuronal circuits. Changes in the weights of existing synapses in networks might depend on voltage-gated potassium currents. We therefore studied the physiological role of potassium channels in memory, concentrating on the Shaker-like Kv1.1, a late rectifying potassium channel that is highly localized within dendrites of hippocampal CA3 pyramidal and dentate gyrus granular cells. Repeated intracerebroventricular injection of antisense oligodeoxyribonucleotide to Kv1.1 reduces expression of its particular intracellular mRNA target, decreases late rectifying K+ current(s) in dentate granule cells, and impairs memory but not other motor or sensory behaviors, in two different learning paradigms, mouse passive avoidance and rat spatial memory. The latter, hippocampal-dependent memory loss occurred in the absence of long-term potentiation changes recorded both from the dentate gyrus or CA1. The specificity of the reversible antisense targeting of mRNA in adult animal brains may avoid irreversible developmental and genetic background effects that accompany transgenic “knockouts”.

Scientific Publication
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