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קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia
Year:
2020
Source of publication :
Scientific Reports
Authors :
גוטויין, אלישע
;
.
דביר, חי
;
.
הניג, חן
;
.
רוזוב, אלכסנדר
;
.
Volume :
10
Co-Authors:

Ross, M. - Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Ofri, R. - Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Aizenberg, I._ Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Abu–Siam, M. - Abu-Siam Veterinary Clinic, Rahat, Israel.
Pe’er, O. -
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Arad, D. - Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Rosov, A. - Institute of Animal Science, Agricultural Research Organization, Volcani Center, Rishon LeZion, Israel.
Gootwine, E. - cInstitute of Animal Science, Agricultural Research Organization, Volcani Center, Rishon LeZion, Israel.
Dvir, H. -cInstitute of Animal Science, Agricultural Research Organization, Volcani Center, Rishon LeZion, Israel,
Honig, H. -
Institute of Animal Science, Agricultural Research Organization, Volcani Center, Rishon LeZion, Israel,
Obolensky, A. - Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Averbukh, E. - Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Banin, E. - Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Gantz, L.  Department of Optometry and Vision Science, Hadassah Academic College, 37 Haneviim St., Jerusalem, 9101001, Israel

  • .

.

 
Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Achromatopsia is an inherited retinal disease characterized by loss of cone photoreceptor function. Day blind CNGA3 mutant Improved Awassi sheep provide a large animal model for achromatopsia. This study measured refractive error and axial length parameters of the eye in this model and evaluated chromatic pupillary light reflex (cPLR) testing as a potential screening test for loss of cone function. Twenty-one CNGA3 mutant, Improved Awassi, 12 control Afec-Assaf and 12 control breed-matched wild-type (WT) Awassi sheep were examined using streak retinoscopy and B-mode ocular ultrasonography. Four CNGA3 mutant and four Afec-Assaf control sheep underwent cPLR testing. Statistical tests showed that day-blind sheep are significantly more myopic than both Afec-Assaf and WT Awassi controls. Day-blind sheep had significantly longer vitreous axial length compared to WT Awassi (1.43 ± 0.13 and 1.23 ± 0.06 cm, respectively, p < 0.0002) and no response to bright red light compared to both controls. Lack of response to bright red light is consistent with cone dysfunction, demonstrating that cPLR can be used to diagnose day blindness in sheep. Day-blind sheep were found to exhibit myopia and increased vitreous chamber depth, providing a naturally occurring large animal model of myopia.

Note:
Related Files :
Experimental models of disease
Eye diseases
עוד תגיות
תוכן קשור
More details
DOI :
10.1038/s41598-020-76205-z
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
51694
Last updated date:
02/03/2022 17:27
Creation date:
15/11/2020 15:14
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Scientific Publication
Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia
10

Ross, M. - Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Ofri, R. - Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Aizenberg, I._ Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Abu–Siam, M. - Abu-Siam Veterinary Clinic, Rahat, Israel.
Pe’er, O. -
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Arad, D. - Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Rosov, A. - Institute of Animal Science, Agricultural Research Organization, Volcani Center, Rishon LeZion, Israel.
Gootwine, E. - cInstitute of Animal Science, Agricultural Research Organization, Volcani Center, Rishon LeZion, Israel.
Dvir, H. -cInstitute of Animal Science, Agricultural Research Organization, Volcani Center, Rishon LeZion, Israel,
Honig, H. -
Institute of Animal Science, Agricultural Research Organization, Volcani Center, Rishon LeZion, Israel,
Obolensky, A. - Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Averbukh, E. - Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Banin, E. - Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Gantz, L.  Department of Optometry and Vision Science, Hadassah Academic College, 37 Haneviim St., Jerusalem, 9101001, Israel

  • .

.

 
Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia

Achromatopsia is an inherited retinal disease characterized by loss of cone photoreceptor function. Day blind CNGA3 mutant Improved Awassi sheep provide a large animal model for achromatopsia. This study measured refractive error and axial length parameters of the eye in this model and evaluated chromatic pupillary light reflex (cPLR) testing as a potential screening test for loss of cone function. Twenty-one CNGA3 mutant, Improved Awassi, 12 control Afec-Assaf and 12 control breed-matched wild-type (WT) Awassi sheep were examined using streak retinoscopy and B-mode ocular ultrasonography. Four CNGA3 mutant and four Afec-Assaf control sheep underwent cPLR testing. Statistical tests showed that day-blind sheep are significantly more myopic than both Afec-Assaf and WT Awassi controls. Day-blind sheep had significantly longer vitreous axial length compared to WT Awassi (1.43 ± 0.13 and 1.23 ± 0.06 cm, respectively, p < 0.0002) and no response to bright red light compared to both controls. Lack of response to bright red light is consistent with cone dysfunction, demonstrating that cPLR can be used to diagnose day blindness in sheep. Day-blind sheep were found to exhibit myopia and increased vitreous chamber depth, providing a naturally occurring large animal model of myopia.

Scientific Publication
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