תפריט נגישות
ניגודיות עדינהניגודיות גבוהה
מונוכרום
הדגשת קישורים
חסימת אנימציה
פונט קריא
סגור
איפוס הגדרות נגישות
להורדת מודול נגישות חינם תפריט נגישותניגודיות עדינהניגודיות גבוההמונוכרוםהדגשת קישוריםחסימת אנימציהפונט קריאסגוראיפוס הגדרות נגישותלהורדת מודול נגישות חינםThe pyrokinin/pheromone biosynthesis-activating neuropeptide (PK/PBAN) family is an important family of peptides in insects which regulate a variety of physiological functions such as development, pre-mating behavior, muscle contraction and induction of cuticular melanization. The family is present in a wide variety of insects and comprises the following C-terminally amidated peptides: PKs, PBANs, diapause hormone (DH), alpha-, beta- and gamma-subesophageal neuropeptides (SGNPs), leucopyrokinin (LPK) and several myotropins (MTs) all of which share a common sequence (FXPRLa). PK/PBAN peptides have been studied for nearly 30 years, mainly in moths, during which many new members have been identified, the genes of the peptides and their receptors have been cloned and characterized, and their distribution in the nervous system studied in many moth species. Their physiological roles have been determined through physiological and behavioral analyses at the whole-organism level, complemented by molecular and cellular studies. The PK/PBAN peptides also form a basis for development of a new-generation of insect-control agents based on neuropeptide antagonists. As a multifunctional family, studies of the physiological role and mode of action of the PK/PBAN peptides at the cellular and molecular level pose many challenges on top of those associated with the use of peptides as a basis for insect control agents. In the past decade our studies focused on a detailed characterization of the structure activity relationship (SAR) of the PK/PBAN family, on the characterization of the PK/PBAN receptors as well as on the rational design of PK/PBAN antagonists. A summary of the achievements gained to date on these topics, their contribution to studies of the mode of action of the PK/PBAN family and their integration in our strategy for the generation a novel family of insecticide prototypes will be presented.
The pyrokinin/pheromone biosynthesis-activating neuropeptide (PK/PBAN) family is an important family of peptides in insects which regulate a variety of physiological functions such as development, pre-mating behavior, muscle contraction and induction of cuticular melanization. The family is present in a wide variety of insects and comprises the following C-terminally amidated peptides: PKs, PBANs, diapause hormone (DH), alpha-, beta- and gamma-subesophageal neuropeptides (SGNPs), leucopyrokinin (LPK) and several myotropins (MTs) all of which share a common sequence (FXPRLa). PK/PBAN peptides have been studied for nearly 30 years, mainly in moths, during which many new members have been identified, the genes of the peptides and their receptors have been cloned and characterized, and their distribution in the nervous system studied in many moth species. Their physiological roles have been determined through physiological and behavioral analyses at the whole-organism level, complemented by molecular and cellular studies. The PK/PBAN peptides also form a basis for development of a new-generation of insect-control agents based on neuropeptide antagonists. As a multifunctional family, studies of the physiological role and mode of action of the PK/PBAN peptides at the cellular and molecular level pose many challenges on top of those associated with the use of peptides as a basis for insect control agents. In the past decade our studies focused on a detailed characterization of the structure activity relationship (SAR) of the PK/PBAN family, on the characterization of the PK/PBAN receptors as well as on the rational design of PK/PBAN antagonists. A summary of the achievements gained to date on these topics, their contribution to studies of the mode of action of the PK/PBAN family and their integration in our strategy for the generation a novel family of insecticide prototypes will be presented.
