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Kusum Dhakar,
Raphy Zarecki,
Daniella van Bommel,
Nadav Knossow,
Shlomit Medina,
Basak Öztürk,
Radi Aly,
Hanan Eizenberg,
Zeev Ronen,
Shiri Freilich

Phenyl urea herbicides are being extensively used for weed control in both agricultural and non-agricultural applications. Linuron is one of the key herbicides in this family and is in a wide use. Like other phenyl urea herbicides, it is known to have toxic effects as a result of its persistence in the environment. The natural removal of linuron from the environment is mainly carried through microbial biodegradation. Some microorganisms have been reported to mineralize linuron completely and utilize it as a carbon and nitrogen source. Variovorax sp. strain SRS 16 is one of the known efficient degraders with recently sequenced genome. The genomic data provide opportunity to use genome scale model for improving biodegradation. The aim of our study is the construction of a genome-scale metabolic model following automatic and manual protocols and its application for improving its metabolic potential. 

פותח על ידי קלירמאש פתרונות בע"מ -
הספר "אוצר וולקני"
אודות
תנאי שימוש
Strategies for enhancing in-vitro degradation of linuron by Variovorax sp. strain SRS 16 under the guidance of metabolic modeling
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Kusum Dhakar,
Raphy Zarecki,
Daniella van Bommel,
Nadav Knossow,
Shlomit Medina,
Basak Öztürk,
Radi Aly,
Hanan Eizenberg,
Zeev Ronen,
Shiri Freilich

Phenyl urea herbicides are being extensively used for weed control in both agricultural and non-agricultural applications. Linuron is one of the key herbicides in this family and is in a wide use. Like other phenyl urea herbicides, it is known to have toxic effects as a result of its persistence in the environment. The natural removal of linuron from the environment is mainly carried through microbial biodegradation. Some microorganisms have been reported to mineralize linuron completely and utilize it as a carbon and nitrogen source. Variovorax sp. strain SRS 16 is one of the known efficient degraders with recently sequenced genome. The genomic data provide opportunity to use genome scale model for improving biodegradation. The aim of our study is the construction of a genome-scale metabolic model following automatic and manual protocols and its application for improving its metabolic potential. 

Scientific Publication
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