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פותח על ידי קלירמאש פתרונות בע"מ -
Interkingdom Signaling Interference: The Effect of Plant-Derived Small Molecules on Quorum Sensing in Plant-Pathogenic Bacteria
Year:
2021
Source of publication :
Annual Review of Phytopathology
Authors :
ג'ושי, ג'נאק ראג'
;
.
דורון-פייגנבאום, עדי
;
.
ידידיה, איריס
;
.
Volume :
Co-Authors:

Janak Raj Joshi 
Netaly Khazanov 
Amy Charkowski 
Adi Faigenboim 
Hanoch Senderowitz
Iris Yedidia

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

In the battle between bacteria and plants, bacteria often use a population density-dependent regulatory system known as quorum sensing (QS) to coordinate virulence gene expression. In response, plants use innate and induced defense mechanisms that include low-molecular-weight compounds, some of which serve as antivirulence agents by interfering with the QS machinery. The best-characterized QS system is driven by the autoinducer N-acyl-homoserine lactone (AHL), which is produced by AHL synthases (LuxI homologs) and perceived by response regulators (LuxR homologs). Several plant compounds have been shown to directly inhibit LuxI or LuxR. Gaining atomic-level insight into their mode of action and how they interfere with QS enzymes supports the identification and design of novel QS inhibitors. Such information can be gained from molecular modeling and docking simulations. The summary of these interactions shows that plant-derived compounds act as interkingdom cues and that these allomones specifically target bacterial communication systems.

Note:
Related Files :
Plant-Pathogenic Bacteria
quorum sensing
Small molecule
עוד תגיות
תוכן קשור
More details
DOI :
10.1146/annurev-phyto-020620-095740
Article number:
0
Affiliations:
Database:
PubMed
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
54965
Last updated date:
02/03/2022 17:27
Creation date:
12/05/2021 21:26
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Scientific Publication
Interkingdom Signaling Interference: The Effect of Plant-Derived Small Molecules on Quorum Sensing in Plant-Pathogenic Bacteria

Janak Raj Joshi 
Netaly Khazanov 
Amy Charkowski 
Adi Faigenboim 
Hanoch Senderowitz
Iris Yedidia

Interkingdom Signaling Interference: The Effect of Plant-Derived Small Molecules on Quorum Sensing in Plant-Pathogenic Bacteria

In the battle between bacteria and plants, bacteria often use a population density-dependent regulatory system known as quorum sensing (QS) to coordinate virulence gene expression. In response, plants use innate and induced defense mechanisms that include low-molecular-weight compounds, some of which serve as antivirulence agents by interfering with the QS machinery. The best-characterized QS system is driven by the autoinducer N-acyl-homoserine lactone (AHL), which is produced by AHL synthases (LuxI homologs) and perceived by response regulators (LuxR homologs). Several plant compounds have been shown to directly inhibit LuxI or LuxR. Gaining atomic-level insight into their mode of action and how they interfere with QS enzymes supports the identification and design of novel QS inhibitors. Such information can be gained from molecular modeling and docking simulations. The summary of these interactions shows that plant-derived compounds act as interkingdom cues and that these allomones specifically target bacterial communication systems.

Scientific Publication
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