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פותח על ידי קלירמאש פתרונות בע"מ -
The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model
Year:
2021
Source of publication :
Israel Journal of Plant Sciences
Authors :
אלמן, ענת
;
.
טלרמן, אלונה
;
.
Volume :
Co-Authors:

Alona Telerman
Yoel Kashman
Rivka Ofir
Anat Elmann

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Plant-derived substances have been shown to affect potential targets in inflammatory diseases. We have previously purified from the desert plant Achillea fragrantissima, a sesquiterpene lactone named achillolide A, and demonstrated its anti-inflammatory activities in cultured brain macrophages named microglial cells. In the present study, we further investigated achillolide A in alleviating atopic dermatitis, a chronic and recurring inflammatory skin disease. We investigated achillolide A for its in vivo anti-inflammatory activity using the oxazolone model of atopic dermatitis in mice, in which oxazolone induces ear swelling. Our results show that mice treated with achillolide A showed a significant decrease in the oxazolone-induced ear swelling. Since macrophages are inflammatory cells that play a pivotal role in the pathogenesis of atopic dermatitis, the anti-inflammatory effects of achillolide A were also studied in spleen cells. We demonstrated that achillolide A reduced the levels of LPS-induced inflammatory cytokines IL-2, IL-6, TNFα, IFNγ and IL-12 that were secreted from cultured splenocytes. These data suggest that achillolide A should be considered for further research in treating atopic dermatitis.

Note:
Related Files :
Achillea fragrantissima
achillolide A
atopic dermatitis
Inflammation
phytochemicals
sesquiterpene-lactones
splenocytes
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
55574
Last updated date:
02/03/2022 17:27
Creation date:
13/07/2021 13:56
Scientific Publication
The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model

Alona Telerman
Yoel Kashman
Rivka Ofir
Anat Elmann

The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model

Plant-derived substances have been shown to affect potential targets in inflammatory diseases. We have previously purified from the desert plant Achillea fragrantissima, a sesquiterpene lactone named achillolide A, and demonstrated its anti-inflammatory activities in cultured brain macrophages named microglial cells. In the present study, we further investigated achillolide A in alleviating atopic dermatitis, a chronic and recurring inflammatory skin disease. We investigated achillolide A for its in vivo anti-inflammatory activity using the oxazolone model of atopic dermatitis in mice, in which oxazolone induces ear swelling. Our results show that mice treated with achillolide A showed a significant decrease in the oxazolone-induced ear swelling. Since macrophages are inflammatory cells that play a pivotal role in the pathogenesis of atopic dermatitis, the anti-inflammatory effects of achillolide A were also studied in spleen cells. We demonstrated that achillolide A reduced the levels of LPS-induced inflammatory cytokines IL-2, IL-6, TNFα, IFNγ and IL-12 that were secreted from cultured splenocytes. These data suggest that achillolide A should be considered for further research in treating atopic dermatitis.

Scientific Publication
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