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פותח על ידי קלירמאש פתרונות בע"מ -
A chromosome-level genome assembly of anesthetic drug-producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids
Year:
2023
Source of publication :
Plant communications
Authors :
מעוז, איתי
;
.
Volume :
Co-Authors:

Wei Zhou
Can Wang
Xiaolong Hao
Fei Chen
Qikai Huang
Tingyao Liu
Jiang Xu
Shuai Guo
Baosheng Liao
Zhixiang Liu
Yue Feng
Yao Wang 
Pan Liao
Jiayu Xue
Min Shi
Itay Maoz
Guoyin Kai 

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Tropane alkaloids (TAs), which are anticholinergic agents, are an essential class of natural compounds, and there is a growing demand for TAs with anesthetic, analgesic, and spasmolytic effects. Anisodus acutangulus (Solanaceae) is a TA-producing plant that was used as an anesthetic in ancient China. In this study, we assembled a high-quality, chromosome-scale genome of A. acutangulus with a contig N50 of 7.4 Mb. A recent whole-genome duplication occurred in A. acutangulus after its divergence from other Solanaceae species, which resulted in the duplication of ADC1 and UGT genes involved in TA biosynthesis. The catalytic activities of H6H enzymes were determined for three Solanaceae plants. On the basis of evolution and co-expressed genes, AaWRKY11 was selected for further analyses, which revealed that its encoded transcription factor promotes TA biosynthesis by activating AaH6H1 expression. These findings provide useful insights into genome evolution related to TA biosynthesis and have potential implications for genetic manipulation of TA-producing plants.

Note:
Related Files :
AaWRKY11
Anisodus acutangulus
biosynthesis
hyoscyamine 6 β-hydroxylase
Tropane alkaloids
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/j.xplc.2023.100680
Article number:
0
Affiliations:
Database:
PubMed
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
66066
Last updated date:
23/10/2023 13:31
Creation date:
23/10/2023 13:18
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Scientific Publication
A chromosome-level genome assembly of anesthetic drug-producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids

Wei Zhou
Can Wang
Xiaolong Hao
Fei Chen
Qikai Huang
Tingyao Liu
Jiang Xu
Shuai Guo
Baosheng Liao
Zhixiang Liu
Yue Feng
Yao Wang 
Pan Liao
Jiayu Xue
Min Shi
Itay Maoz
Guoyin Kai 

A chromosome-level genome assembly of anesthetic drug-producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids

Tropane alkaloids (TAs), which are anticholinergic agents, are an essential class of natural compounds, and there is a growing demand for TAs with anesthetic, analgesic, and spasmolytic effects. Anisodus acutangulus (Solanaceae) is a TA-producing plant that was used as an anesthetic in ancient China. In this study, we assembled a high-quality, chromosome-scale genome of A. acutangulus with a contig N50 of 7.4 Mb. A recent whole-genome duplication occurred in A. acutangulus after its divergence from other Solanaceae species, which resulted in the duplication of ADC1 and UGT genes involved in TA biosynthesis. The catalytic activities of H6H enzymes were determined for three Solanaceae plants. On the basis of evolution and co-expressed genes, AaWRKY11 was selected for further analyses, which revealed that its encoded transcription factor promotes TA biosynthesis by activating AaH6H1 expression. These findings provide useful insights into genome evolution related to TA biosynthesis and have potential implications for genetic manipulation of TA-producing plants.

Scientific Publication
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