Co-Authors:
Huberman, L., Department of Food Sciences, Volcani Center, ARO, Beit Dagan, Israel
Gollop, N., Department of Food Sciences, Volcani Center, ARO, Beit Dagan, Israel
Mumcuoglu, K.Y., Department of Parasitology, Hebrew University, Hadassah Medical School, Jerusalem, Israel, Department of Parasitology, Hebrew University, Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel
Breuer, E., Department of Medicinal Chemistry, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Bhusare, S.R., Department of Medicinal Chemistry, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Shai, Y., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Galun, R., Department of Parasitology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
Abstract:
Low molecular weight compounds were isolated by high-performance liquid chromatography from the maggot or haemolymph extracts of Lucilia sericata (Meigen) (Diptera: Calliphoridae). Using gas chromatography-mass spectrometry analysis, three compounds were obtained: p-hydroxybenzoic acid (molecular weight 138 Da), p-hydroxyphenylacetic acid (molecular weight 152 Da) and octahydro-dipyrrolo[1,2-a;1′,2′-d] pyrazine-5,10-dione (molecular weight 194 Da), also known as the cyclic dimer of proline (or proline diketopiperazine or cyclo[Pro,Pro]). All three molecules revealed antibacterial activity when tested against Micrococcus luteus and/or Pseudomonas aeruginosa, and the effect was even more pronounced when these molecules were tested in combination and caused lysis of these bacteria. © 2007 The Royal Entomological Society.
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