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A novel function of red wine polyphenols in humans: Prevention of absorption of cytotoxic lipid peroxidation products
Year:
2008
Source of publication :
FASEB Journal
Authors :
Kanner, Joseph
;
.
Volume :
22
Co-Authors:
Gorelik, S., Department of Pharmaceutics, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Ligumsky, M., Gastrointestinal Unit, Division of Internal Medicine, Hadassah Medical Center, Jerusalem, Israel
Kohen, R., Department of Pharmaceutics, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Kanner, J., Department of Food Science, ARO, Volcani Center, Bet Dagan, Israel, Department of Food Science, ARO, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
41
To page:
46
(
Total pages:
6
)
Abstract:
Current evidence supports a contribution of polyphenols to the prevention of cardiovascular disease, but their mechanisms of action are not understood. We investigated the impact of red wine polyphenols on postprandial cytotoxic lipid peroxidation products (MDA) levels in humans. In a randomized, crossover study, the effect of red wine polyphenols on postprandial levels of plasma and urine MDA was investigated. Three meals of 250 g turkey cutlets supplemented by water (A); soaked in red wine after heating plus 200 ml of red wine (B); or soaked in red wine prior to heating plus 200 ml of red wine (C) were administered to 10 healthy volunteers. Subject baseline plasma levels of MDA were 50 ± 20 nM. After a meal of turkey meat cutlets, plasma MDA levels increased by 160 nM (P<0.0001); after (B) there was a 75% reduction in the absorption of MDA (P<0.0001). However, after (C), the elevation of plasma MDA was completely prevented (P<0.0001). Similar results were obtained for MDA accumulation in urine. Our study suggests that red wine polyphenols exert a beneficial effect by the novel new function, absorption inhibition of the lipotoxin MDA. These findings explain the potentially harmful effects of oxidized fats found in foods and the important benefit of dietary polyphenols in the meal. © FASEB.
Note:
Related Files :
adult
antioxidants
Blood
drug effect
Female
flavonoids
Male
phenols
Show More
Related Content
More details
DOI :
10.1096/fj.07-9041com
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
18941
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:25
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Scientific Publication
A novel function of red wine polyphenols in humans: Prevention of absorption of cytotoxic lipid peroxidation products
22
Gorelik, S., Department of Pharmaceutics, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Ligumsky, M., Gastrointestinal Unit, Division of Internal Medicine, Hadassah Medical Center, Jerusalem, Israel
Kohen, R., Department of Pharmaceutics, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
Kanner, J., Department of Food Science, ARO, Volcani Center, Bet Dagan, Israel, Department of Food Science, ARO, Volcani Center, Bet Dagan 50250, Israel
A novel function of red wine polyphenols in humans: Prevention of absorption of cytotoxic lipid peroxidation products
Current evidence supports a contribution of polyphenols to the prevention of cardiovascular disease, but their mechanisms of action are not understood. We investigated the impact of red wine polyphenols on postprandial cytotoxic lipid peroxidation products (MDA) levels in humans. In a randomized, crossover study, the effect of red wine polyphenols on postprandial levels of plasma and urine MDA was investigated. Three meals of 250 g turkey cutlets supplemented by water (A); soaked in red wine after heating plus 200 ml of red wine (B); or soaked in red wine prior to heating plus 200 ml of red wine (C) were administered to 10 healthy volunteers. Subject baseline plasma levels of MDA were 50 ± 20 nM. After a meal of turkey meat cutlets, plasma MDA levels increased by 160 nM (P<0.0001); after (B) there was a 75% reduction in the absorption of MDA (P<0.0001). However, after (C), the elevation of plasma MDA was completely prevented (P<0.0001). Similar results were obtained for MDA accumulation in urine. Our study suggests that red wine polyphenols exert a beneficial effect by the novel new function, absorption inhibition of the lipotoxin MDA. These findings explain the potentially harmful effects of oxidized fats found in foods and the important benefit of dietary polyphenols in the meal. © FASEB.
Scientific Publication
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