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The functional metabolism of vitamin D in chicks fed low-calcium and low-phosphorus diets
Year:
1975
Source of publication :
BBA - General Subjects
Authors :
Bär, Arie
;
.
Edelstein, Samuel
;
.
Hurvitz, Shmuel
;
.
Volume :
385
Co-Authors:
Edelstein, S., Department of Endocrinology, Municipal Governmental Medical Centre, Ichilov Hospital, Tel Aviv-Jaffo, Israel, Institute of Animal Sciences, Agricultural Research Organisation, The Volcani Centre, Bet Dagan, Israel
Harell, A., Department of Endocrinology, Municipal Governmental Medical Centre, Ichilov Hospital, Tel Aviv-Jaffo, Israel, Institute of Animal Sciences, Agricultural Research Organisation, The Volcani Centre, Bet Dagan, Israel
Bar, A., Department of Endocrinology, Municipal Governmental Medical Centre, Ichilov Hospital, Tel Aviv-Jaffo, Israel, Institute of Animal Sciences, Agricultural Research Organisation, The Volcani Centre, Bet Dagan, Israel
Hurwitz, S., Department of Endocrinology, Municipal Governmental Medical Centre, Ichilov Hospital, Tel Aviv-Jaffo, Israel, Institute of Animal Sciences, Agricultural Research Organisation, The Volcani Centre, Bet Dagan, Israel
Facilitators :
From page:
438
To page:
442
(
Total pages:
5
)
Abstract:
Radioactively labelled cholecalciferol was administered continuously to chicks that were fed normal, low-calcium and low-phosphorus diets. It has been possible to show that under such steady state conditions with regard to cholecalciferol, and mineral restriction, the animal reacts by increased accumulation of 1,25-dihydroxycholecalciferol in the intestinal and the kidney cell, which was associated in the intestine with an increased calcium-binding activity. A similar accumulation of 1,25-dihydroxycholecalciferol in bone was not noticed. It is proposed that the intestine and the kidney, but not bone, are the main target organs for cholecalciferol in the maintenance of calcium homeostasis, and that both calcium and phosphorus play a role in the regulation of the formation and subsequent function of 1,25-dihydroxycholecalciferol. © 1975.
Note:
Related Files :
Animal
Bone
calcitriol
cell nucleus
Chickens
Deficiency Diseases
drug accumulation
Intestinal Mucosa
Kidney
Minerals
Show More
Related Content
More details
DOI :
10.1016/0304-4165(75)90376-1
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
19350
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:28
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Scientific Publication
The functional metabolism of vitamin D in chicks fed low-calcium and low-phosphorus diets
385
Edelstein, S., Department of Endocrinology, Municipal Governmental Medical Centre, Ichilov Hospital, Tel Aviv-Jaffo, Israel, Institute of Animal Sciences, Agricultural Research Organisation, The Volcani Centre, Bet Dagan, Israel
Harell, A., Department of Endocrinology, Municipal Governmental Medical Centre, Ichilov Hospital, Tel Aviv-Jaffo, Israel, Institute of Animal Sciences, Agricultural Research Organisation, The Volcani Centre, Bet Dagan, Israel
Bar, A., Department of Endocrinology, Municipal Governmental Medical Centre, Ichilov Hospital, Tel Aviv-Jaffo, Israel, Institute of Animal Sciences, Agricultural Research Organisation, The Volcani Centre, Bet Dagan, Israel
Hurwitz, S., Department of Endocrinology, Municipal Governmental Medical Centre, Ichilov Hospital, Tel Aviv-Jaffo, Israel, Institute of Animal Sciences, Agricultural Research Organisation, The Volcani Centre, Bet Dagan, Israel
The functional metabolism of vitamin D in chicks fed low-calcium and low-phosphorus diets
Radioactively labelled cholecalciferol was administered continuously to chicks that were fed normal, low-calcium and low-phosphorus diets. It has been possible to show that under such steady state conditions with regard to cholecalciferol, and mineral restriction, the animal reacts by increased accumulation of 1,25-dihydroxycholecalciferol in the intestinal and the kidney cell, which was associated in the intestine with an increased calcium-binding activity. A similar accumulation of 1,25-dihydroxycholecalciferol in bone was not noticed. It is proposed that the intestine and the kidney, but not bone, are the main target organs for cholecalciferol in the maintenance of calcium homeostasis, and that both calcium and phosphorus play a role in the regulation of the formation and subsequent function of 1,25-dihydroxycholecalciferol. © 1975.
Scientific Publication
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