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Use of 1α-Hydroxyvitamin D3 in the Prevention of Bovine Parturient Paresis. IX. Early and Late Effects of a Single Injection
Year:
1987
Source of publication :
Journal of Dairy Science
Authors :
Perlman, Rivka
;
.
Volume :
70
Co-Authors:
Sachs, M., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel
Perlman, R., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel
Bar, A., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel
Facilitators :
From page:
1671
To page:
1675
(
Total pages:
5
)
Abstract:
Israeli Friesian cows in the third or later lactation were injected intramuscularly (serratus muscle of the neck) with 1α-hydroxyvitamin D3 in propylene glycol in order to compare the short-term and long-term effects of the drug. Following injection of 700 μg 1α-hydroxyvitamin D3, the D-derivative appeared in the plasma after 12 h and reached a peak 24 h after injection. Plasma 1,25-dihydroxyvitamin D increased as early as 6 h and peaked at 24 h. Plasma calcium increased after 6 h and peaked 4 to 5 d after the injection. The administration of a single dose of 350 μg 1α-hydroxyvitamin D3 at 7 to 8 d before calving did not prevent periparturient hypocalcaemia observed in the uninjected control cows. A single injection of 700 μg 1α-hydroxyvitamin D3 7 to 8 d before parturition prevented hypocalcemia at calving. There were no significant differences in plasma calcium 4 to 21 d after calving between the injected and control cows nor were there any cases of delayed postparturient hypocalcemia or milk fever. Results suggest that 700 μg 1α-hydroxyvitamin D3 prolonged the calcemic effect of the drug and prevented hypocalcemia at parturition, even if administered 6 to 8 d before calving. © 1987, American Dairy Science Association. All rights reserved.
Note:
Related Files :
1-hydroxycholecalciferol
alfacalcidol
Animal
animal disease
Animals
Blood
calcitriol
cattle
Female
pregnancy
Show More
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More details
DOI :
10.3168/jds.S0022-0302(87)80195-9
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
19357
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:28
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Scientific Publication
Use of 1α-Hydroxyvitamin D3 in the Prevention of Bovine Parturient Paresis. IX. Early and Late Effects of a Single Injection
70
Sachs, M., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel
Perlman, R., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel
Bar, A., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel
Use of 1α-Hydroxyvitamin D3 in the Prevention of Bovine Parturient Paresis. IX. Early and Late Effects of a Single Injection
Israeli Friesian cows in the third or later lactation were injected intramuscularly (serratus muscle of the neck) with 1α-hydroxyvitamin D3 in propylene glycol in order to compare the short-term and long-term effects of the drug. Following injection of 700 μg 1α-hydroxyvitamin D3, the D-derivative appeared in the plasma after 12 h and reached a peak 24 h after injection. Plasma 1,25-dihydroxyvitamin D increased as early as 6 h and peaked at 24 h. Plasma calcium increased after 6 h and peaked 4 to 5 d after the injection. The administration of a single dose of 350 μg 1α-hydroxyvitamin D3 at 7 to 8 d before calving did not prevent periparturient hypocalcaemia observed in the uninjected control cows. A single injection of 700 μg 1α-hydroxyvitamin D3 7 to 8 d before parturition prevented hypocalcemia at calving. There were no significant differences in plasma calcium 4 to 21 d after calving between the injected and control cows nor were there any cases of delayed postparturient hypocalcemia or milk fever. Results suggest that 700 μg 1α-hydroxyvitamin D3 prolonged the calcemic effect of the drug and prevented hypocalcemia at parturition, even if administered 6 to 8 d before calving. © 1987, American Dairy Science Association. All rights reserved.
Scientific Publication
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