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Different signal transduction cascades are activated simultaneously in the rat insular cortex and hippocampus following novel taste learning
Year:
2006
Source of publication :
European Journal of Neuroscience
Authors :
Meiri, Noam
;
.
Volume :
24
Co-Authors:
Yefet, K., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Merhav, M., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Kuulmann-Vander, S., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Elkobi, A., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Belelovsky, K., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Jacobson-Pick, S., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Meiri, N., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Rosenblum, K., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Facilitators :
From page:
1434
To page:
1442
(
Total pages:
9
)
Abstract:
Novel taste learning is a robust one-trial incidental learning process, dependent on functional activity of the insular (taste) cortex. In contrast to that of the cortex, the role of the hippocampus in taste learning is controversial. We set out to identify the time courses of the activation of mitogen-associated protein kinase (MAPK), transcription factor cAMP-response element-binding protein (CREB) and Akt/PKB (protein kinase B) in the insular cortex and hippocampus of rats subsequent to novel taste learning. Following taste learning, an early response (20 min) occurred at the same time in the insular cortex and the hippocampus. However, whereas MAPK was activated specifically in the insular cortex, CREB and Akt were phosphorylated in the hippocampus but not in the cortex. In addition, the immediate early gene, CCAAT/enhancer binding protein (C/EBPβ) was induced in both the hippocampus and the insular cortex 18 h following taste learning. The results demonstrate, for the first time, correlative activation and gene expression in the hippocampus following novel taste learning. Moreover, the results suggest that different signal transduction cascades necessary for taste learning are activated in concert in different brain structures, to enable taste learning and consolidation. © The Authors (2006).
Note:
Related Files :
animal experiment
Animals
C/EBP
gene expression
Male
Molecular Biology
taste
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More details
DOI :
10.1111/j.1460-9568.2006.05009.x
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
19448
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:29
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Scientific Publication
Different signal transduction cascades are activated simultaneously in the rat insular cortex and hippocampus following novel taste learning
24
Yefet, K., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Merhav, M., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Kuulmann-Vander, S., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Elkobi, A., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Belelovsky, K., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Jacobson-Pick, S., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Meiri, N., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Rosenblum, K., Department for Neurobiology and Ethology, Center for Brain and Behaviour, University of Haifa, Haifa 31905, Israel
Different signal transduction cascades are activated simultaneously in the rat insular cortex and hippocampus following novel taste learning
Novel taste learning is a robust one-trial incidental learning process, dependent on functional activity of the insular (taste) cortex. In contrast to that of the cortex, the role of the hippocampus in taste learning is controversial. We set out to identify the time courses of the activation of mitogen-associated protein kinase (MAPK), transcription factor cAMP-response element-binding protein (CREB) and Akt/PKB (protein kinase B) in the insular cortex and hippocampus of rats subsequent to novel taste learning. Following taste learning, an early response (20 min) occurred at the same time in the insular cortex and the hippocampus. However, whereas MAPK was activated specifically in the insular cortex, CREB and Akt were phosphorylated in the hippocampus but not in the cortex. In addition, the immediate early gene, CCAAT/enhancer binding protein (C/EBPβ) was induced in both the hippocampus and the insular cortex 18 h following taste learning. The results demonstrate, for the first time, correlative activation and gene expression in the hippocampus following novel taste learning. Moreover, the results suggest that different signal transduction cascades necessary for taste learning are activated in concert in different brain structures, to enable taste learning and consolidation. © The Authors (2006).
Scientific Publication
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