Co-Authors:
Nachtomi, E., Fels Research Institute, Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140, United States
Sarma, D.S.R., Fels Research Institute, Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140, United States
Abstract:
Tube feeding of [14C]Jethylene dibromide (EDB) to non-fasted rats resulted in the incorporation of the radioactivity into liver DNA, RNA and protein. Using alkaline and neutral sucrose gradients, it was observed that administration of the pesticide to non-fasted rat caused slower sedimentation of liver DNA in alkaline and not in neutral sucrose gradients. Slower sedimentation of liver DNA in alkaline sucrose gradients was apparent within 2 hr after the administration of a dose of 22 mg/100 g or 4 hr after a dose of 7.5 mg/100 g of body weight. Using a dose of 7.5 mg/100 g, the EDB-induced liver DNA damage was repaired significantly by 17.5 hr and almost completely by 96 hr. Administration of diethyldithiocarbamate, a free radical scavenger, did not inhibit liver DNA damage caused by EDB. © 1977.
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