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Repair of rat liver DNA in vivo damaged by ethylene dibromide
Year:
1977
Source of publication :
Biochemical Pharmacology
Authors :
Nachtomi, Edna
;
.
Volume :
26
Co-Authors:
Nachtomi, E., Fels Research Institute, Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140, United States
Sarma, D.S.R., Fels Research Institute, Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140, United States
Facilitators :
From page:
1941
To page:
1945
(
Total pages:
5
)
Abstract:
Tube feeding of [14C]Jethylene dibromide (EDB) to non-fasted rats resulted in the incorporation of the radioactivity into liver DNA, RNA and protein. Using alkaline and neutral sucrose gradients, it was observed that administration of the pesticide to non-fasted rat caused slower sedimentation of liver DNA in alkaline and not in neutral sucrose gradients. Slower sedimentation of liver DNA in alkaline sucrose gradients was apparent within 2 hr after the administration of a dose of 22 mg/100 g or 4 hr after a dose of 7.5 mg/100 g of body weight. Using a dose of 7.5 mg/100 g, the EDB-induced liver DNA damage was repaired significantly by 17.5 hr and almost completely by 96 hr. Administration of diethyldithiocarbamate, a free radical scavenger, did not inhibit liver DNA damage caused by EDB. © 1977.
Note:
Related Files :
Animal
DNA
Male
oral drug administration
proteins
RNA
Show More
Related Content
More details
DOI :
10.1016/0006-2952(77)90170-8
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
19499
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:29
Scientific Publication
Repair of rat liver DNA in vivo damaged by ethylene dibromide
26
Nachtomi, E., Fels Research Institute, Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140, United States
Sarma, D.S.R., Fels Research Institute, Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140, United States
Repair of rat liver DNA in vivo damaged by ethylene dibromide
Tube feeding of [14C]Jethylene dibromide (EDB) to non-fasted rats resulted in the incorporation of the radioactivity into liver DNA, RNA and protein. Using alkaline and neutral sucrose gradients, it was observed that administration of the pesticide to non-fasted rat caused slower sedimentation of liver DNA in alkaline and not in neutral sucrose gradients. Slower sedimentation of liver DNA in alkaline sucrose gradients was apparent within 2 hr after the administration of a dose of 22 mg/100 g or 4 hr after a dose of 7.5 mg/100 g of body weight. Using a dose of 7.5 mg/100 g, the EDB-induced liver DNA damage was repaired significantly by 17.5 hr and almost completely by 96 hr. Administration of diethyldithiocarbamate, a free radical scavenger, did not inhibit liver DNA damage caused by EDB. © 1977.
Scientific Publication
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