Co-Authors:
Sundaram, M., Great Lakes Forestry Centre, Canadian Forest Service, Natural Resources Canada, P.O. Box 490, Sault Ste. Marie, Ont. P6A 5M7, Canada, Department of Microbiology, University of Guelph, Guelph, Ont. N1G2W1, Canada
Palli, S.R., Great Lakes Forestry Centre, Canadian Forest Service, Natural Resources Canada, P.O. Box 490, Sault Ste. Marie, Ont. P6A 5M7, Canada
Ishaaya, I., Department of Entomology, Agricultural Research Organization, Volcani Centre, Bet Dagan 50250, Israel
Krell, P.J., Department of Microbiology, University of Guelph, Guelph, Ont. N1G2W1, Canada
Retnakaran, A., Great Lakes Forestry Centre, Canadian Forest Service, Natural Resources Canada, P.O. Box 490, Sault Ste. Marie, Ont. P6A 5M7, Canada
Abstract:
Four ecdysone agonists, RH-5849, RH-5992, RH-0345, and RH-2485, were tested for toxicity against fifth-instar larvae of Choristoneura fumiferana. RH-2485 was the most toxic (LD50 = 1.05 ng/larva) followed by RH-5992 (LD50 = 8.8 ng/larva), RH-0345 (LD50 = 41.0 ng/larva), and RH-5849 (LD50 = 236.9 ng/larva). The relative potencies of these compounds to induce the transcription factor Choristoneura hormone receptor 3 (CHR3) was studied. Detectable levels of CHR3 mRNA were induced by RH-2485 at a concentration as low as 1.5 ng/larva, but similar inductions required concentrations as high as 7.5 ng of RH-5992/larva, 37.5 of RH-0345/larva, and 187.5 of RH-5849/larva. The order of potency of these four ecdysone agonists for inducing CHR3 mRNA is the same as their larval toxicity.
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