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Spermiogenic, epididymal, and spermatozoal damage induced by a peritesticular injection of ethylene dibromide to rams
Year:
1983
Source of publication :
Animal Reproduction Science
Authors :
Amir, David
;
.
Volume :
6
Co-Authors:
Amir, D., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A., Agricultural Research Organization, The Volcani Center, Institute of Animal Science, POB 6, Bet Dagan 50-200, Israel
Gledhill, B.L., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A.
Garner, D.L., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A.
Nicolle, J.C., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A., Station de Physiologie de la Reproduction, 37380 Nouzilly, France
Tadmor, A., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A., The Kimron Veterinary Institute, Bet Dagan 50-200, Israel
Facilitators :
From page:
35
To page:
50
(
Total pages:
16
)
Abstract:
The effects of a peritesticular injection of ethylene dibromide (EDB) on the germ cells, epididymis, and spermatozoa of rams was examined by removing each injected testis and epididymis at different times after treatment and by monitoring the seminal characteristics of ejaculates. A high incidence of abnormal elongating and elongated spermatids was observed in the testes of treated rams 48 h after injection. At this time the epithelium of the corpus and cauda epididymidis was damaged in the majority of observed rams, and the spermatozoa in these segments were abnormal, mainly with acrosomal defects, denuded forms and denuded tailless forms. Apparent phagocytosis of spermatozoa was also observed in these portions of the epididymal duct. Ejaculates collected as early as 48 h after injection had a very low sperm density and large percentages of spermatozoa with acrosomal and tail abnormalities. A dose-reponse effect was obtained, and the reversibility of the effect of a low dose of EDB on sperm morphology was demonstrated in the rams by semen examination. © 1983.
Note:
Related Files :
1,2 dibromoethane
animal experiment
Animalia
drug toxicity
epididymis
Histology
intoxication
sheep
spermatozoon
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More details
DOI :
10.1016/0378-4320(83)90005-2
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
19754
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:31
Scientific Publication
Spermiogenic, epididymal, and spermatozoal damage induced by a peritesticular injection of ethylene dibromide to rams
6
Amir, D., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A., Agricultural Research Organization, The Volcani Center, Institute of Animal Science, POB 6, Bet Dagan 50-200, Israel
Gledhill, B.L., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A.
Garner, D.L., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A.
Nicolle, J.C., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A., Station de Physiologie de la Reproduction, 37380 Nouzilly, France
Tadmor, A., The Lawrence Livermore National Laboratory, Biomedical Sciences Division, L-452, University of California, Livermore, CA 94550 U.S.A., The Kimron Veterinary Institute, Bet Dagan 50-200, Israel
Spermiogenic, epididymal, and spermatozoal damage induced by a peritesticular injection of ethylene dibromide to rams
The effects of a peritesticular injection of ethylene dibromide (EDB) on the germ cells, epididymis, and spermatozoa of rams was examined by removing each injected testis and epididymis at different times after treatment and by monitoring the seminal characteristics of ejaculates. A high incidence of abnormal elongating and elongated spermatids was observed in the testes of treated rams 48 h after injection. At this time the epithelium of the corpus and cauda epididymidis was damaged in the majority of observed rams, and the spermatozoa in these segments were abnormal, mainly with acrosomal defects, denuded forms and denuded tailless forms. Apparent phagocytosis of spermatozoa was also observed in these portions of the epididymal duct. Ejaculates collected as early as 48 h after injection had a very low sperm density and large percentages of spermatozoa with acrosomal and tail abnormalities. A dose-reponse effect was obtained, and the reversibility of the effect of a low dose of EDB on sperm morphology was demonstrated in the rams by semen examination. © 1983.
Scientific Publication
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