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Fine mapping of a QTL for fertility on BTA7 and its association with a CNV in the israeli holsteins
Year:
2011
Source of publication :
G3: Genes, Genomes, Genetics
Authors :
Ron, Micha
;
.
Seroussi, Eyal
;
.
Shirak, Andrey
;
.
Weller, Joel Ira
;
.
Volume :
1
Co-Authors:
Glick, G., The Hebrew University of Jerusalem, The Robert H. Smith Faculty of Agriculture, Rehovot, 76100, Israel
Shirak, A., Institute of Animal Sciences, ARO, The Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Sciences, ARO, The Volcani Center, Bet Dagan 50250, Israel
Zeron, Y., Sion, AI Institute, Shikmim 79800, Israel
Ezra, E., Israel Cattle Breeders Association, Caesaria Industrial Park, Caesaria 38900, Israel
Weller, J.I., Institute of Animal Sciences, ARO, The Volcani Center, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Sciences, ARO, The Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
65
To page:
74
(
Total pages:
10
)
Abstract:
A quantitative trait locus (QTL) affecting female fertility, scored as the inverse of the number of inseminations to conception, on Bos taurus chromosome 7 was detected by a daughter design analysis of the Israeli Holstein population (P > 0.0003). Sires of five of the 10 families analyzed were heterozygous for the QTL. The 95% confidence interval of the QTL spans 27 cM from the centromere. Seven hundred and four SNP markers on the Illumina BovineSNP50 BeadChip within the QTL confidence interval were tested for concordance. A single SNP, NGS-58779, was heterozygous for all the five QTL heterozygous patriarchs, and homozygous for the remaining five QTL homozygous sires. A significant effect on fertility was associated with this marker in the sample of 900 sires genotyped (P > 10-6). Haplotype phase was the same for four of the five segregating sires. Thus concordance was obtained in nine of the ten families. We identified a common haplotype region associated with the rare and economically favorable allele of the SNP, spanning 270 kbp on BTA7 upstream to 4.72 Mbp. Eleven genes found in the common haplotype region should be considered as positional candidates for the identification of the causative quantitative trait nucleotide. Copy number variation was found in one of these genes, KIAA1683. Four gene variants were identified, but only the number of copies of a specific variant (V1) was significantly associated with breeding values of sires for fertility. © 2011 by the Giora Glick et al.
Note:
Related Files :
Copy number
Female-fertility
Gene-variants
KIAA1683
Locus (QTL)
quantitative trait
Variation (CNV)
Show More
Related Content
More details
DOI :
10.1534/g3.111.000299
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
19969
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:33
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Scientific Publication
Fine mapping of a QTL for fertility on BTA7 and its association with a CNV in the israeli holsteins
1
Glick, G., The Hebrew University of Jerusalem, The Robert H. Smith Faculty of Agriculture, Rehovot, 76100, Israel
Shirak, A., Institute of Animal Sciences, ARO, The Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Sciences, ARO, The Volcani Center, Bet Dagan 50250, Israel
Zeron, Y., Sion, AI Institute, Shikmim 79800, Israel
Ezra, E., Israel Cattle Breeders Association, Caesaria Industrial Park, Caesaria 38900, Israel
Weller, J.I., Institute of Animal Sciences, ARO, The Volcani Center, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Sciences, ARO, The Volcani Center, Bet Dagan 50250, Israel
Fine mapping of a QTL for fertility on BTA7 and its association with a CNV in the israeli holsteins
A quantitative trait locus (QTL) affecting female fertility, scored as the inverse of the number of inseminations to conception, on Bos taurus chromosome 7 was detected by a daughter design analysis of the Israeli Holstein population (P > 0.0003). Sires of five of the 10 families analyzed were heterozygous for the QTL. The 95% confidence interval of the QTL spans 27 cM from the centromere. Seven hundred and four SNP markers on the Illumina BovineSNP50 BeadChip within the QTL confidence interval were tested for concordance. A single SNP, NGS-58779, was heterozygous for all the five QTL heterozygous patriarchs, and homozygous for the remaining five QTL homozygous sires. A significant effect on fertility was associated with this marker in the sample of 900 sires genotyped (P > 10-6). Haplotype phase was the same for four of the five segregating sires. Thus concordance was obtained in nine of the ten families. We identified a common haplotype region associated with the rare and economically favorable allele of the SNP, spanning 270 kbp on BTA7 upstream to 4.72 Mbp. Eleven genes found in the common haplotype region should be considered as positional candidates for the identification of the causative quantitative trait nucleotide. Copy number variation was found in one of these genes, KIAA1683. Four gene variants were identified, but only the number of copies of a specific variant (V1) was significantly associated with breeding values of sires for fertility. © 2011 by the Giora Glick et al.
Scientific Publication
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