נגישות
menu      
Advanced Search
Syntax
Search...
Volcani treasures
About
Terms of use
Manage
Community:
אסיף מאגר המחקר החקלאי
Powered by ClearMash Solutions Ltd -
Alterations to the permeability of liposome membranes by the solasodine-based glycoalkaloids solasonine and solamargine
Year:
1992
Source of publication :
Phytochemistry
Authors :
Weissenberg, Martin
;
.
Volume :
31
Co-Authors:
Roddick, J.G., Department of Biological Sciences, University of Exeter, Exeter, United Kingdom
Rijnenberg, A.L., Department of Biological Sciences, University of Exeter, Exeter, United Kingdom
Weissenberg, M., Department of Biological Sciences, University of Exeter, Exeter, United Kingdom, Department of Chemistry of Natural Products, A.R.O., The Volcani Center, P.O.B. 6, Bet Dagan, Israel
Facilitators :
From page:
1951
To page:
1954
(
Total pages:
4
)
Abstract:
The effects of the solasodine-based glycoalkaloids, solasonine and solamargine, on the permeability of phosphatidylcholine liposomes containing different free sterols have been investigated. Solamargine was consistently the more active compound and caused major lysis of cholesterol-, stigmasterol- and ergosterol-containing liposomes, while solasonine was without effect on cholesterol liposomes and only slightly disruptive to stigmasterol and ergosterol liposomes. Liposomes lacking sterols were not lysed by either compound. In vitro, solamargine also bound effectively with all three sterols, but solasonine did so only with cholesterol and to a lesser degree than solamargine. Both glycoalkaloids, but especially solamargine, caused greater leakage from cholesterol liposomes when the sterol level was increased. Neither compound disrupted cholesterol liposomes at sub-neutral pH, but solamargine became highly active at pH 7 and above, while solasonine remained inactive. Findings are compared with similar properties of the structurally related, but solanidine-based, glycoalkaloids of potato, solanine and chaconine. © 1992.
Note:
Related Files :
Glycoalkaloids
liposome permeability
solamargine.
Solanaceae
Solanum sp.
Solasonine
Show More
Related Content
More details
DOI :
10.1016/0031-9422(92)80339-G
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
19978
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:33
You may also be interested in
Scientific Publication
Alterations to the permeability of liposome membranes by the solasodine-based glycoalkaloids solasonine and solamargine
31
Roddick, J.G., Department of Biological Sciences, University of Exeter, Exeter, United Kingdom
Rijnenberg, A.L., Department of Biological Sciences, University of Exeter, Exeter, United Kingdom
Weissenberg, M., Department of Biological Sciences, University of Exeter, Exeter, United Kingdom, Department of Chemistry of Natural Products, A.R.O., The Volcani Center, P.O.B. 6, Bet Dagan, Israel
Alterations to the permeability of liposome membranes by the solasodine-based glycoalkaloids solasonine and solamargine
The effects of the solasodine-based glycoalkaloids, solasonine and solamargine, on the permeability of phosphatidylcholine liposomes containing different free sterols have been investigated. Solamargine was consistently the more active compound and caused major lysis of cholesterol-, stigmasterol- and ergosterol-containing liposomes, while solasonine was without effect on cholesterol liposomes and only slightly disruptive to stigmasterol and ergosterol liposomes. Liposomes lacking sterols were not lysed by either compound. In vitro, solamargine also bound effectively with all three sterols, but solasonine did so only with cholesterol and to a lesser degree than solamargine. Both glycoalkaloids, but especially solamargine, caused greater leakage from cholesterol liposomes when the sterol level was increased. Neither compound disrupted cholesterol liposomes at sub-neutral pH, but solamargine became highly active at pH 7 and above, while solasonine remained inactive. Findings are compared with similar properties of the structurally related, but solanidine-based, glycoalkaloids of potato, solanine and chaconine. © 1992.
Scientific Publication
You may also be interested in