אסיף מאגר המחקר החקלאי

Immunization of cattle against Theileria annulata using killed schizont vaccine

Year:

1977

Source of publication :

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Volume :

3

Co-Authors:

Pipano, E., Kimron Veterinary Institute, P.O.B. 12, Bet Dagan, 50200, Israel
Goldman, M., Kimron Veterinary Institute, P.O.B. 12, Bet Dagan, 50200, Israel
Samish, M., Kimron Veterinary Institute, P.O.B. 12, Bet Dagan, 50200, Israel
Friedhoff, K.T., Department of Parasitology, School of Veterinary Medicine, D-3000 Hannover 71, Germany

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Abstract:

Cultured bovine lymphoid cells infected with Theileria annulata schizonts were disrupted by freeze drying and sonication. Calves were inoculated with fractions of the disrupted cells with and without Freund's adjuvant, and their degree of immunity was ascertained by challenge with infected blood and with infected ticks. Serum antibody levels were determined by immunofluorescence tests. The highest degree of protection against blood challenge was found in calves receiving vaccine plus adjuvant, the particulate portion of the disrupted parasites being more effective than the soluble. High antibody titers developed in all animals receiving vaccine with adjuvant, but no relationship was observed between antibody titer and protection against challenge. Calves that were immune to blood challenge as a result of receiving killed schizonts remained completely susceptible to infective Theileria particles from ticks. © 1977.

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