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SYNTHESIS AND PHOTOCYTOTOXICITY OF SOME NEW SUBSTITUTED PHTHALOCYANINES
Year:
1989
Source of publication :
Photochemistry and Photobiology
Authors :
Rosenthal, Ionel
;
.
Volume :
49
Co-Authors:
LEZNOFF, C.C., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
VIGH, S., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
SVIRSKAYA, P.I., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
GREENBERG, S., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
DREW, D.M., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
BEN‐HUR, E., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
ROSENTHAL, I., Department of Food Science, A.R.O, Volcani Center, P.O. Box 6, Bet Dagan, Israel
Facilitators :
From page:
279
To page:
284
(
Total pages:
6
)
Abstract:
Abstract Some new, ring‐substituted phthalocyanines have been synthesized and underwent preliminary testing for photodynamic activity using the colony forming ability of Chinese hamster cells in culture as an endpoint. Using 4‐(3‐N, N‐diethylaminopropyl)phthalonitrile as a precursor, the previously unknown metal‐free 2,9,16,23‐tetra‐(3‐N, N‐diethylaminopropyl)phthalocyanine was prepared and converted to its zinc (II) and its cationic water‐soluble 2,9,16,23‐tetramethylammonium zinc (II) iodide derivatives. Other new phthalocyanine derivatives tested, include a 2,9,16,23‐tetra(2‐hydroxymethyl‐2‐methyIbutoxy)phthalocyaninato zinc (II) and 2,3,9,10,16,17,23,24‐octahydroxyphthalocyaninato zinc (II) derivatives. Boron tribromide cleavage of the newly prepared and fully characterized 2,3,9,10,16,17,23,24‐octamethoxyphthalocyanine gave the unstable metal‐free octahydroxyphthalocy‐anine, which could only be characterized by ultraviolet‐visible, NMR and IR spectroscopy. Copyright © 1989, Wiley Blackwell. All rights reserved
Note:
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More details
DOI :
10.1111/j.1751-1097.1989.tb04107.x
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
20111
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:34
Scientific Publication
SYNTHESIS AND PHOTOCYTOTOXICITY OF SOME NEW SUBSTITUTED PHTHALOCYANINES
49
LEZNOFF, C.C., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
VIGH, S., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
SVIRSKAYA, P.I., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
GREENBERG, S., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
DREW, D.M., Department of Chemistry, York University, North York, Toronto, Ontario, M3J 1P3, Canada
BEN‐HUR, E., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
ROSENTHAL, I., Department of Food Science, A.R.O, Volcani Center, P.O. Box 6, Bet Dagan, Israel
SYNTHESIS AND PHOTOCYTOTOXICITY OF SOME NEW SUBSTITUTED PHTHALOCYANINES
Abstract Some new, ring‐substituted phthalocyanines have been synthesized and underwent preliminary testing for photodynamic activity using the colony forming ability of Chinese hamster cells in culture as an endpoint. Using 4‐(3‐N, N‐diethylaminopropyl)phthalonitrile as a precursor, the previously unknown metal‐free 2,9,16,23‐tetra‐(3‐N, N‐diethylaminopropyl)phthalocyanine was prepared and converted to its zinc (II) and its cationic water‐soluble 2,9,16,23‐tetramethylammonium zinc (II) iodide derivatives. Other new phthalocyanine derivatives tested, include a 2,9,16,23‐tetra(2‐hydroxymethyl‐2‐methyIbutoxy)phthalocyaninato zinc (II) and 2,3,9,10,16,17,23,24‐octahydroxyphthalocyaninato zinc (II) derivatives. Boron tribromide cleavage of the newly prepared and fully characterized 2,3,9,10,16,17,23,24‐octamethoxyphthalocyanine gave the unstable metal‐free octahydroxyphthalocy‐anine, which could only be characterized by ultraviolet‐visible, NMR and IR spectroscopy. Copyright © 1989, Wiley Blackwell. All rights reserved
Scientific Publication
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