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Unequivocal determination of sire allele origin for multiallelic microsatellites when only the sire and progeny are genotyped
Year:
1993
Source of publication :
Animal Genetics
Authors :
Ron, Micha
;
.
Weller, Joel Ira
;
.
Wyler, A.
;
.
Volume :
24
Co-Authors:
Ron, M., Institute of Animal Sciences, Volcani Center, PO Box 6, Bet Dagan, 50250, Israel
Band, M., Institute of Animal Sciences, Volcani Center, PO Box 6, Bet Dagan, 50250, Israel
Wyler, A.
Weller, J.I., Institute of Animal Sciences, Volcani Center, PO Box 6, Bet Dagan, 50250, Israel
Facilitators :
From page:
171
To page:
176
(
Total pages:
6
)
Abstract:
The effect of a segregating economic trait locus (ETL) can be detected with the aid of a linked genetic marker, if specific alleles of each locus are in association among the individuals genotyped for the genetic marker. For dairy cattle this can be achieved by application of the ‘granddaughter design’. If only the sires and their sons are genotyped for the genetic markers, then the allele origin of sons having the same genotypes as their sires cannot be determined. Seven sires and 101 sons were genotyped for five microsatellites. The mean frequency of heterozygous sires was 77%. The mean number of alleles per locus was 8.2. Frequency of informative sons per locus ranged from 60% to 80% with a mean of 72%. With highly polymorphic microsatellites, at least 60% more grandsire families can be included in the analysis, and the number of sons assayed can be reduced by 40%, as compared to diallelic markers. © 1993 International Society for Animal Genetics
Note:
Related Files :
Alleles
Animal
cattle
DNA‐microsatellite
genetic markers
Genetics
Heterozygote
Male
Show More
Related Content
More details
DOI :
10.1111/j.1365-2052.1993.tb00282.x
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
20121
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:34
Scientific Publication
Unequivocal determination of sire allele origin for multiallelic microsatellites when only the sire and progeny are genotyped
24
Ron, M., Institute of Animal Sciences, Volcani Center, PO Box 6, Bet Dagan, 50250, Israel
Band, M., Institute of Animal Sciences, Volcani Center, PO Box 6, Bet Dagan, 50250, Israel
Wyler, A.
Weller, J.I., Institute of Animal Sciences, Volcani Center, PO Box 6, Bet Dagan, 50250, Israel
Unequivocal determination of sire allele origin for multiallelic microsatellites when only the sire and progeny are genotyped
The effect of a segregating economic trait locus (ETL) can be detected with the aid of a linked genetic marker, if specific alleles of each locus are in association among the individuals genotyped for the genetic marker. For dairy cattle this can be achieved by application of the ‘granddaughter design’. If only the sires and their sons are genotyped for the genetic markers, then the allele origin of sons having the same genotypes as their sires cannot be determined. Seven sires and 101 sons were genotyped for five microsatellites. The mean frequency of heterozygous sires was 77%. The mean number of alleles per locus was 8.2. Frequency of informative sons per locus ranged from 60% to 80% with a mean of 72%. With highly polymorphic microsatellites, at least 60% more grandsire families can be included in the analysis, and the number of sons assayed can be reduced by 40%, as compared to diallelic markers. © 1993 International Society for Animal Genetics
Scientific Publication
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