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FEBS Letters
Altstein, M., Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
Dudai, Y., Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
Vogel, Z., Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
Two proteolytic activities that degrade [Leu5]enkephalin were found in Torpedo californica electric organ. One is a soluble aminopeptidase that degrades enkephalin at the Tyr1-Gly2 peptide bond, and the second is an endopeptidase that degrades enkephalin at the Gly3-Phe4 peptide bond. The aminopeptidase is inhibited by low concentrations of puromycin and bestatin. More than 60% of the endopeptidase is associated with the particulate fraction and is almost completely inhibited by low concentrations of captopril (SQ 14225) or SQ 20881 (potent inhibitors of angiotensin converting enzyme). Thiorphan and phoshoramidon (potent enkephalinase inhibitors) are much less effective. The pattern of cleavage and inhibition of the particulate endopeptidase thus resembles that of angiotensin converting enzyme. © 1984.
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Enkephalin degrading enzymes are present in the electric organ of Torpedo californica
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Altstein, M., Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
Dudai, Y., Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
Vogel, Z., Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
Enkephalin degrading enzymes are present in the electric organ of Torpedo californica
Two proteolytic activities that degrade [Leu5]enkephalin were found in Torpedo californica electric organ. One is a soluble aminopeptidase that degrades enkephalin at the Tyr1-Gly2 peptide bond, and the second is an endopeptidase that degrades enkephalin at the Gly3-Phe4 peptide bond. The aminopeptidase is inhibited by low concentrations of puromycin and bestatin. More than 60% of the endopeptidase is associated with the particulate fraction and is almost completely inhibited by low concentrations of captopril (SQ 14225) or SQ 20881 (potent inhibitors of angiotensin converting enzyme). Thiorphan and phoshoramidon (potent enkephalinase inhibitors) are much less effective. The pattern of cleavage and inhibition of the particulate endopeptidase thus resembles that of angiotensin converting enzyme. © 1984.
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