Co-Authors:
Sadot, E., The Volcani Center, The Institute of Plant Sciences, Bet-Dagan, Israel
Abstract:
The cytoskeleton is a network of filamentous protein polymers that regulate various aspects of the lives of eukaryotic cells, among them shape, adhesion, motility and division. Plant-derived compounds have made a major contribution to human medicine for thousands of years and continue to serve as an indispensable source of therapeutic substances. Drug discovery from medicinal plants has yielded compounds that act on the cytoskeleton; some of these are in clinical use, including colchicines, the vinca alkaloids, taxanes and podophyllotoxins. Compounds that are produced in living organisms usually have a complex chemical structure that is naturally designed to interact with cellular components. Therefore, although high-throughput screens based on mixtures of natural products are more difficult to handle and less favoured by the pharmaceutical companies, they still have recognized, highly valuable advantages. This review summarizes the history and recent developments in the field of plant compounds that act on the cytoskeleton. © Springer-Verlag Berlin Heidelberg 2014.
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