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Effect of hydrocortisone and glucagon on glycogen metabolism in the fetal rat liver
Year:
1975
Source of publication :
BBA - General Subjects
Authors :
Pines, Mark
;
.
Volume :
411
Co-Authors:
Pines, M., Pediatric Research Laboratory, Department of Biology, Ben Gurion University of the Negev, Beersheva, Israel
Bashan, N., Pediatric Research Laboratory, Department of Biology, Ben Gurion University of the Negev, Beersheva, Israel
Moses, S.W., Pediatric Research Laboratory, Department of Biology, Ben Gurion University of the Negev, Beersheva, Israel
Facilitators :
From page:
369
To page:
376
(
Total pages:
8
)
Abstract:
1. 1. Hydrocortisone increase in vivo incorporation of [14C]glucose into fetal liver glycogen in the last days of gestation, whereas in glucagon-treated fetuses, a slight decrease in the incorporation rate was found. 2. 2. Hydrocortisone increases total synthetase activity as that of synthetase a but was without effect on fetal liver glycogen phosphorylase. 3. 3. Glucagon causes a slight increase in phosphorylase a activity on days 19-21, and was without effect on the activities of synthetase a and total synthetase. 4. 4. Dibutyryl cyclic AMP had no effect on the key enzymes of glycogen metabolism 1 h after injection in utero, whereas after 6 h an increase in phosphorylase a activity was found without any change in synthetase a activity. © 1975.
Note:
Related Files :
Animal
bucladesine
Cyclic AMP
Female
fetus
glycogen synthase
metabolism
phosphorylase
pregnancy
unclassified drug
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More details
DOI :
10.1016/0304-4165(75)90316-5
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
21267
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:42
Scientific Publication
Effect of hydrocortisone and glucagon on glycogen metabolism in the fetal rat liver
411
Pines, M., Pediatric Research Laboratory, Department of Biology, Ben Gurion University of the Negev, Beersheva, Israel
Bashan, N., Pediatric Research Laboratory, Department of Biology, Ben Gurion University of the Negev, Beersheva, Israel
Moses, S.W., Pediatric Research Laboratory, Department of Biology, Ben Gurion University of the Negev, Beersheva, Israel
Effect of hydrocortisone and glucagon on glycogen metabolism in the fetal rat liver
1. 1. Hydrocortisone increase in vivo incorporation of [14C]glucose into fetal liver glycogen in the last days of gestation, whereas in glucagon-treated fetuses, a slight decrease in the incorporation rate was found. 2. 2. Hydrocortisone increases total synthetase activity as that of synthetase a but was without effect on fetal liver glycogen phosphorylase. 3. 3. Glucagon causes a slight increase in phosphorylase a activity on days 19-21, and was without effect on the activities of synthetase a and total synthetase. 4. 4. Dibutyryl cyclic AMP had no effect on the key enzymes of glycogen metabolism 1 h after injection in utero, whereas after 6 h an increase in phosphorylase a activity was found without any change in synthetase a activity. © 1975.
Scientific Publication
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