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Formation in vitro of 5α-dihydrotestosterone and other 5α-reduced metabolites of 3H-testosterone by the seminiferous tubules and interstitial tissue from immature and mature rat testes
Year:
1973
Source of publication :
Endocrinology
Authors :
Folman, Yeshayahu
;
.
Volume :
92
Co-Authors:
Folman, Y., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, Division of Physiology and Biochemistry of Reproduction, Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, The Volcani Institute of Agricultural Research, Bet-Dagan, Israel
Ahmad, N., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, Division of Physiology and Biochemistry of Reproduction, Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States
Sowell, J.G., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, Division of Physiology and Biochemistry of Reproduction, Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States
Eik-Nes, K.B., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, Division of Physiology and Biochemistry of Reproduction, Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States
Facilitators :
From page:
41
To page:
47
(
Total pages:
7
)
Abstract:
Testes of 13 immature and mature rats were separated into seminiferous tubules and interstitial tissue and incubated with 3H-testosterone (T) and an NADPH generating system. The per unit tissue wt conversion to 3H-5α-dihydrotestosterone (DHT) by incubated tubules from mature rats was much higher than that by incubated interstitial tissue. Both tissue components left more than 85% of the 3H-T substrate unconverted and total α-reduction of 3H-T was similar in both tubules and interstitial tissue. Interstitial tissue from testes of immature rats, however, converted more 3H-T to 3H-DHT than the testicular tubules and total 5α-reduction of T by the Leydig cells was 20 times greater than that of the tubules. © 1973 by The Endocrine Society.
Note:
Related Files :
Animal
biosynthesis
Carbon
Chromatography, Gas
Male
metabolism
testis
tritium
Show More
Related Content
More details
DOI :
10.1210/endo-92-1-41
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
21303
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:43
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Scientific Publication
Formation in vitro of 5α-dihydrotestosterone and other 5α-reduced metabolites of 3H-testosterone by the seminiferous tubules and interstitial tissue from immature and mature rat testes
92
Folman, Y., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, Division of Physiology and Biochemistry of Reproduction, Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, The Volcani Institute of Agricultural Research, Bet-Dagan, Israel
Ahmad, N., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, Division of Physiology and Biochemistry of Reproduction, Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States
Sowell, J.G., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, Division of Physiology and Biochemistry of Reproduction, Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States
Eik-Nes, K.B., Division of Physiology and Biochemistry of Reproduction, Department of Physiology, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States, Division of Physiology and Biochemistry of Reproduction, Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, CA, 90033, United States
Formation in vitro of 5α-dihydrotestosterone and other 5α-reduced metabolites of 3H-testosterone by the seminiferous tubules and interstitial tissue from immature and mature rat testes
Testes of 13 immature and mature rats were separated into seminiferous tubules and interstitial tissue and incubated with 3H-testosterone (T) and an NADPH generating system. The per unit tissue wt conversion to 3H-5α-dihydrotestosterone (DHT) by incubated tubules from mature rats was much higher than that by incubated interstitial tissue. Both tissue components left more than 85% of the 3H-T substrate unconverted and total α-reduction of 3H-T was similar in both tubules and interstitial tissue. Interstitial tissue from testes of immature rats, however, converted more 3H-T to 3H-DHT than the testicular tubules and total 5α-reduction of T by the Leydig cells was 20 times greater than that of the tubules. © 1973 by The Endocrine Society.
Scientific Publication
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