Melzer, E., Gastroenterology Department, Tel Aviv University, Tel Aviv, 52621, Israel
Lang, A., Gastroenterology Department, Tel Aviv University, Tel Aviv, 52621, Israel
Gopher, A., Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 52621, Israel
Almog, S., Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 52621, Israel
Ezra, D., Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 52621, Israel
Bar-Meir, S., Gastroenterology Department, Tel Aviv University, Tel Aviv, 52621, Israel

We investigated in the rat the effect of the H+/K+-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity. © 1995 Springer-Verlag.