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Omeprazole has no effect on acetaminophen kinetics in the rat
Year:
1995
Authors :
Ezra, David
;
.
Volume :
20
Co-Authors:
Melzer, E., Gastroenterology Department, Tel Aviv University, Tel Aviv, 52621, Israel
Lang, A., Gastroenterology Department, Tel Aviv University, Tel Aviv, 52621, Israel
Gopher, A., Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 52621, Israel
Almog, S., Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 52621, Israel
Ezra, D., Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 52621, Israel
Bar-Meir, S., Gastroenterology Department, Tel Aviv University, Tel Aviv, 52621, Israel
Facilitators :
From page:
125
To page:
128
(
Total pages:
4
)
Abstract:
We investigated in the rat the effect of the H+/K+-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity. © 1995 Springer-Verlag.
Note:
Related Files :
acetaminophen
Animal
animal experiment
cytochrome P450
drug effect
intravenous drug administration
Male
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Related Content
More details
DOI :
10.1007/BF03226366
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
21466
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:44
Scientific Publication
Omeprazole has no effect on acetaminophen kinetics in the rat
20
Melzer, E., Gastroenterology Department, Tel Aviv University, Tel Aviv, 52621, Israel
Lang, A., Gastroenterology Department, Tel Aviv University, Tel Aviv, 52621, Israel
Gopher, A., Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 52621, Israel
Almog, S., Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 52621, Israel
Ezra, D., Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 52621, Israel
Bar-Meir, S., Gastroenterology Department, Tel Aviv University, Tel Aviv, 52621, Israel
Omeprazole has no effect on acetaminophen kinetics in the rat
We investigated in the rat the effect of the H+/K+-ATPase inhibitor, omeprazole, on the kinetics of acetaminophen. Two groups of rats were treated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearance were determined in the conscious rat. Elimination rate constant, elimination half life time, clearance and volume of distribution of acetaminophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore, will not increase susceptibility to acetaminophen toxicity. © 1995 Springer-Verlag.
Scientific Publication
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