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Nuclear and mitochondr1al DNA synthesis during yeast sporulation
Year:
1974
Source of publication :
Experimental Cell Research
Authors :
Salts, Yehiam
;
.
Volume :
83
Co-Authors:
Piñon, R., Department of Genetics, University of Washington, Seattle, WA 98195, United States
Salts, Y., Department of Genetics, University of Washington, Seattle, WA 98195, United States
Simchen, G., Department of Genetics, University of Washington, Seattle, WA 98195, United States
Facilitators :
From page:
231
To page:
238
(
Total pages:
8
)
Abstract:
Nuclear and mitochondrial DNA synthesis during sporulation of Saccharomyces cerevisiae has been studied in a wild-type (aα) strain and 3 sporulation deficient strains. We find that in a strain carrying a dominant mutation which prevents sporulation, nuclear DNA synthesis is initiated but not completed; mitochondrial DNA synthesis, on the other hand, does take place. In aa and αα diploids no initiation of nuclear DNA synthesis is seen to occur, and only a very low level of mitochondrial DNA synthesis is observed. We conclude that mitochondrial DNA synthesis in sporulation medium is uncoupled from nuclear DNA synthesis. In addition, the steps at which the sporulation process is arrested in aa and αα cells and in the dominant mutant can be ordered in time as being before and after the initiation of nuclear DNA synthesis. © 1974.
Note:
Related Files :
cell nucleus
Centrifugation, Density Gradient
DNA
mitochondria
mutation
tritium
Show More
Related Content
More details
DOI :
10.1016/0014-4827(74)90334-6
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
21513
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:44
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Scientific Publication
Nuclear and mitochondr1al DNA synthesis during yeast sporulation
83
Piñon, R., Department of Genetics, University of Washington, Seattle, WA 98195, United States
Salts, Y., Department of Genetics, University of Washington, Seattle, WA 98195, United States
Simchen, G., Department of Genetics, University of Washington, Seattle, WA 98195, United States
Nuclear and mitochondr1al DNA synthesis during yeast sporulation
Nuclear and mitochondrial DNA synthesis during sporulation of Saccharomyces cerevisiae has been studied in a wild-type (aα) strain and 3 sporulation deficient strains. We find that in a strain carrying a dominant mutation which prevents sporulation, nuclear DNA synthesis is initiated but not completed; mitochondrial DNA synthesis, on the other hand, does take place. In aa and αα diploids no initiation of nuclear DNA synthesis is seen to occur, and only a very low level of mitochondrial DNA synthesis is observed. We conclude that mitochondrial DNA synthesis in sporulation medium is uncoupled from nuclear DNA synthesis. In addition, the steps at which the sporulation process is arrested in aa and αα cells and in the dominant mutant can be ordered in time as being before and after the initiation of nuclear DNA synthesis. © 1974.
Scientific Publication
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