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Hydrogen-deuterium exchange in γirradiated polycrystalline DL-alanine: A spin-trapping and E.S.R. Study
Year:
1981
Authors :
Rosenthal, Ionel
;
.
Volume :
40
Co-Authors:
Mossoba, M.M., Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20205, United States
Rosenthal, I., Department of Technology, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Riesz, P., Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20205, United States
Facilitators :
From page:
397
To page:
411
(
Total pages:
15
)
Abstract:
The hydrogen-deuterium exchange reactions in γirradiated DL-alanine in the solid state were investigated by spin-trapping and electron spin resonance (e.s.r) using selectively deuterated DL-alanine. Subsequent to γradiolysis at 30°C, polycrystalline DL-alanine was dissolved in aqueous solutions of 2-methyl-2-nitrosopropane and the extent of H-D exchange of the deamination radicals was followed by e.s.r. After formation of the deamination radicals, four exchange reactions were found to occur between the radicals and the surrounding undamaged molecules. The first reaction, which occurs between the hydrogens of the C-2 carbon of the radicals and those of the methyl groups of the neighbouring molecules, can be followed at room temperature. The three other reactions could be conveniently monitored in γirradiated polycrystalline alanine at 110°C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical. © 1981 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Note:
Related Files :
deuterium hydrogen exchange
Electron Spin Resonance Spectroscopy
free radicals
gamma radiation
Gamma Rays
radioisotope
Show More
Related Content
More details
DOI :
10.1080/09553008114551351
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
21572
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:45
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Scientific Publication
Hydrogen-deuterium exchange in γirradiated polycrystalline DL-alanine: A spin-trapping and E.S.R. Study
40
Mossoba, M.M., Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20205, United States
Rosenthal, I., Department of Technology, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Riesz, P., Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20205, United States
Hydrogen-deuterium exchange in γirradiated polycrystalline DL-alanine: A spin-trapping and E.S.R. Study
The hydrogen-deuterium exchange reactions in γirradiated DL-alanine in the solid state were investigated by spin-trapping and electron spin resonance (e.s.r) using selectively deuterated DL-alanine. Subsequent to γradiolysis at 30°C, polycrystalline DL-alanine was dissolved in aqueous solutions of 2-methyl-2-nitrosopropane and the extent of H-D exchange of the deamination radicals was followed by e.s.r. After formation of the deamination radicals, four exchange reactions were found to occur between the radicals and the surrounding undamaged molecules. The first reaction, which occurs between the hydrogens of the C-2 carbon of the radicals and those of the methyl groups of the neighbouring molecules, can be followed at room temperature. The three other reactions could be conveniently monitored in γirradiated polycrystalline alanine at 110°C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical. © 1981 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Scientific Publication
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