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Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age
Year:
2015
Source of publication :
Cell Metabolism
Authors :
Kraut-Cohen, Judith
;
.
Volume :
22
Co-Authors:
Zwighaft, Z., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Aviram, R., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Shalev, M., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Rousso-Noori, L., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Kraut-Cohen, J., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Golik, M., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Brandis, A., Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel
Reinke, H., University of Düsseldorf, Medical Faculty, Institute of Clinical Chemistry and Laboratory Diagnostics, Düsseldorf, Germany, IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
Aharoni, A., Department of Plant and Environmental Science, Weizmann Institute of Science, Rehovot, Israel
Kahana, C., Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Asher, G., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Facilitators :
From page:
874
To page:
885
(
Total pages:
12
)
Abstract:
Polyamines are essential polycations present in all living cells. Polyamine levels are maintained from the diet and de novo synthesis, and their decline with age is associated with various pathologies. Here we show that polyamine levels oscillate in a daily manner. Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1:CLOCK to conserved DNA elements. In turn, polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1. Importantly, we found that the decline in polyamine levels with age in mice is associated with a longer circadian period that can be reversed upon polyamine supplementation in the diet. Our findings suggest a crosstalk between circadian clocks and polyamine biosynthesis and open new possibilities for nutritional interventions against the decay in clock's function with age. © 2015 Elsevier Inc.
Note:
Related Files :
Animal
Animals
Blood
gene expression
Genetics
Male
metabolism
mice
PER2 protein
Show More
Related Content
More details
DOI :
10.1016/j.cmet.2015.09.011
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
21876
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:47
Scientific Publication
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age
22
Zwighaft, Z., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Aviram, R., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Shalev, M., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Rousso-Noori, L., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Kraut-Cohen, J., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Golik, M., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Brandis, A., Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel
Reinke, H., University of Düsseldorf, Medical Faculty, Institute of Clinical Chemistry and Laboratory Diagnostics, Düsseldorf, Germany, IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
Aharoni, A., Department of Plant and Environmental Science, Weizmann Institute of Science, Rehovot, Israel
Kahana, C., Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Asher, G., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age
Polyamines are essential polycations present in all living cells. Polyamine levels are maintained from the diet and de novo synthesis, and their decline with age is associated with various pathologies. Here we show that polyamine levels oscillate in a daily manner. Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1:CLOCK to conserved DNA elements. In turn, polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1. Importantly, we found that the decline in polyamine levels with age in mice is associated with a longer circadian period that can be reversed upon polyamine supplementation in the diet. Our findings suggest a crosstalk between circadian clocks and polyamine biosynthesis and open new possibilities for nutritional interventions against the decay in clock's function with age. © 2015 Elsevier Inc.
Scientific Publication
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