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Enzymatic resolutions of cyclic amino alcohol precursors
Year:
1989
Authors :
Hönig, Helmut
;
.
Volume :
Co-Authors:
Hönig, H., Institute of Organic Chemistry, Graz University of Technology, A-8010 Graz, Austria
Seufer-Wasserthal, P., Institute of Organic Chemistry, Graz University of Technology, A-8010 Graz, Austria
Fülöp, F., Institute of Pharmaceutical Chemistry, University Medical School, Szeged, Hungary
Facilitators :
From page:
2341
To page:
2345
(
Total pages:
5
)
Abstract:
Racemic butyrates of trans-2-azido as well as trans-2-nitro and trans-2-cyano cycloalkanols were hydrolysed to the corresponding optically active alcohols with the aid of lipases from Candida cylindracea and Pseudomonas sp. respectively. These precursors of amino alcohols could be produced in optical yields ranging from 85 to >98% e.e. Differences in the catalytic behaviour of the two enzymes depending on ring sizes were observed.
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DOI :
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
21902
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:47
Scientific Publication
Enzymatic resolutions of cyclic amino alcohol precursors
Hönig, H., Institute of Organic Chemistry, Graz University of Technology, A-8010 Graz, Austria
Seufer-Wasserthal, P., Institute of Organic Chemistry, Graz University of Technology, A-8010 Graz, Austria
Fülöp, F., Institute of Pharmaceutical Chemistry, University Medical School, Szeged, Hungary
Enzymatic resolutions of cyclic amino alcohol precursors
Racemic butyrates of trans-2-azido as well as trans-2-nitro and trans-2-cyano cycloalkanols were hydrolysed to the corresponding optically active alcohols with the aid of lipases from Candida cylindracea and Pseudomonas sp. respectively. These precursors of amino alcohols could be produced in optical yields ranging from 85 to >98% e.e. Differences in the catalytic behaviour of the two enzymes depending on ring sizes were observed.
Scientific Publication
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