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Sugar induced cell death in yeast is dependent on the rate of sugar phosphorylation as determined by Arabidopsis thaliana hexokinase
Year:
1997
Source of publication :
Cell Death and Differentiation
Authors :
Dai, Nir
;
.
Granot, David
;
.
Volume :
4
Co-Authors:
Granot, D., Dept. of Fld. Crops and Nat. Rsrc., Volcani Center, Inst. Fld./Gdn. Crops, Agric Res. O., PO Box 6, Bet Dagan 50250, Israel
Dai, N., Dept. of Fld. Crops and Nat. Rsrc., Volcani Center, Inst. Fld./Gdn. Crops, Agric Res. O., PO Box 6, Bet Dagan 50250, Israel
Facilitators :
From page:
555
To page:
559
(
Total pages:
5
)
Abstract:
Sugars like glucose and fructose induce death of yeast cells within a few hours, in the absence of additional nutrients to support growth, while cells incubated in water remain viable for weeks. This sugar-induced cell death (SICD) by glucose and fructose required glucose or fructose phosphorylation since yeast cells deficient in hexose phosphorylation did not die. However, when hexose phosphorylation is restored by complementation with Arabidopsis thaliana hexokinase, the cells died. The affinity of A. thaliana hexokinase is about 400 times higher for glucose than for fructose, therefore, A. thaliana hexokinase was further utilized to study the role of hexose phosphorylation in SICD. The rate of SICD of hexokinase-deficient yeast cells expressing A. thaliana hexokinase was significantly slower in fructose than in glucose, indicating that SICD is determined by the rate of hexose phosphorylation. The significance of hexose phosphorylation and its role in SICD is discussed.
Note:
Related Files :
fructose
glucose
Hexose phosphorylation
Saccharomyces cerevisiae
Sugar induced cell death (SICD)
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Related Content
More details
DOI :
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
21903
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:47
Scientific Publication
Sugar induced cell death in yeast is dependent on the rate of sugar phosphorylation as determined by Arabidopsis thaliana hexokinase
4
Granot, D., Dept. of Fld. Crops and Nat. Rsrc., Volcani Center, Inst. Fld./Gdn. Crops, Agric Res. O., PO Box 6, Bet Dagan 50250, Israel
Dai, N., Dept. of Fld. Crops and Nat. Rsrc., Volcani Center, Inst. Fld./Gdn. Crops, Agric Res. O., PO Box 6, Bet Dagan 50250, Israel
Sugar induced cell death in yeast is dependent on the rate of sugar phosphorylation as determined by Arabidopsis thaliana hexokinase
Sugars like glucose and fructose induce death of yeast cells within a few hours, in the absence of additional nutrients to support growth, while cells incubated in water remain viable for weeks. This sugar-induced cell death (SICD) by glucose and fructose required glucose or fructose phosphorylation since yeast cells deficient in hexose phosphorylation did not die. However, when hexose phosphorylation is restored by complementation with Arabidopsis thaliana hexokinase, the cells died. The affinity of A. thaliana hexokinase is about 400 times higher for glucose than for fructose, therefore, A. thaliana hexokinase was further utilized to study the role of hexose phosphorylation in SICD. The rate of SICD of hexokinase-deficient yeast cells expressing A. thaliana hexokinase was significantly slower in fructose than in glucose, indicating that SICD is determined by the rate of hexose phosphorylation. The significance of hexose phosphorylation and its role in SICD is discussed.
Scientific Publication
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