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Inhibition of cell division and cell elongation in higher plants by inhibitors of DNA synthesis
Year:
1965
Source of publication :
Developmental Biology
Authors :
Nitsan, Joseph
;
.
Volume :
12
Co-Authors:
Nitsan, J., Division of Biology, California Institute of Technology, Pasadena, CA, United States
Lang, A., Division of Biology, California Institute of Technology, Pasadena, CA, United States
Facilitators :
From page:
358
To page:
376
(
Total pages:
19
)
Abstract:
Lettuce seedlings were incubated in the presence and absence of gibberellin (GA3) in solutions containing different inhibitors of DNA synthesis. GA3 promoted the elongation of the lettuce hypocotyl in the dark, and of both hypocotyl and cotyledons in the light; 50% growth inhibition was obtained by 3 × 10-7 M 5-fluorodeoxyuridine (FUDR). Inhibition produced by FUDR at 10-7 to 10-5 M was completely reversed by 10-4 M thymidine, but not by uridine. The inhibition produced by amethopterin was only partly reversed by thymidine; 50% inhibition was obtained at 10-7 M of amethopterin, 10-5 M of mitomycin C, and 2 × 10-3 M of phenethyl alcohol. In the inhibited tissues both cell division and cell elongation were suppressed. In epicotyls of decapitated lentil seedlings, which grow mainly by cell elongation, cell elongation was promoted by GA3 and was inhibited by FUDR at 10-7 to 10-5 M. This inhibition was again reversed by thymidine, but not by uridine. The possible relationship between DNA synthesis and cell elongation in GA3-promoted tissues is discussed. © 1965.
Note:
Related Files :
biosynthesis
DNA
drug effect
gibberellins
Growth, Development and Aging
methotrexate
plant
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More details
DOI :
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
22546
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:52
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Scientific Publication
Inhibition of cell division and cell elongation in higher plants by inhibitors of DNA synthesis
12
Nitsan, J., Division of Biology, California Institute of Technology, Pasadena, CA, United States
Lang, A., Division of Biology, California Institute of Technology, Pasadena, CA, United States
Inhibition of cell division and cell elongation in higher plants by inhibitors of DNA synthesis
Lettuce seedlings were incubated in the presence and absence of gibberellin (GA3) in solutions containing different inhibitors of DNA synthesis. GA3 promoted the elongation of the lettuce hypocotyl in the dark, and of both hypocotyl and cotyledons in the light; 50% growth inhibition was obtained by 3 × 10-7 M 5-fluorodeoxyuridine (FUDR). Inhibition produced by FUDR at 10-7 to 10-5 M was completely reversed by 10-4 M thymidine, but not by uridine. The inhibition produced by amethopterin was only partly reversed by thymidine; 50% inhibition was obtained at 10-7 M of amethopterin, 10-5 M of mitomycin C, and 2 × 10-3 M of phenethyl alcohol. In the inhibited tissues both cell division and cell elongation were suppressed. In epicotyls of decapitated lentil seedlings, which grow mainly by cell elongation, cell elongation was promoted by GA3 and was inhibited by FUDR at 10-7 to 10-5 M. This inhibition was again reversed by thymidine, but not by uridine. The possible relationship between DNA synthesis and cell elongation in GA3-promoted tissues is discussed. © 1965.
Scientific Publication
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