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Insect neuropeptide antagonists
Year:
2001
Authors :
Altstein, Miriam
;
.
Volume :
60
Co-Authors:
Altstein, M., Institute of Plant Protection, Volcani Center, Bet Dagan, Israel, Dept. of Entomology, Volcani Center, Bet Dagan, 50250, Israel
Facilitators :
From page:
460
To page:
473
(
Total pages:
14
)
Abstract:
The development of a new integrated approach to the generation of a novel type of insect neuropeptide (Np) antagonists and putative insect control agents based on backbone cyclic compounds is described. The approach, termed the backbone cyclic neuropeptide-based antagonist (BBC-NBA), was applied to the insect pyrokinin (PK)/pheromone biosynthesis activating neuropeptide (PBAN) family as a model, and led to the discovery of a potent linear lead antagonist and several highly potent, metabolically stable BBC antagonists, devoid of agonistic activity, which inhibited PBAN-mediated activities in moths in vivo. This review briefly summarizes our knowledge of insect Nps, describes the PK/PBAN Np family, presents the basic concepts behind the BBC-NBA approach, and introduces the advantages of this method for generation of Np agonists, antagonists and insecticide prototype molecules. © 2002 Wiley Periodicals, Inc.
Note:
Related Files :
Animals
biosynthesis
insect hormones
insecticides
Lepidoptera
metabolism
neuropeptide
Review
Show More
Related Content
More details
DOI :
10.1002/1097-0282(2001)60:6<460::AID-BIP10181>3.0.CO;2-Y
Article number:
Affiliations:
Database:
Scopus
Publication Type:
Review
;
.
Language:
English
Editors' remarks:
ID:
23702
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:01
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Scientific Publication
Insect neuropeptide antagonists
60
Altstein, M., Institute of Plant Protection, Volcani Center, Bet Dagan, Israel, Dept. of Entomology, Volcani Center, Bet Dagan, 50250, Israel
Insect neuropeptide antagonists
The development of a new integrated approach to the generation of a novel type of insect neuropeptide (Np) antagonists and putative insect control agents based on backbone cyclic compounds is described. The approach, termed the backbone cyclic neuropeptide-based antagonist (BBC-NBA), was applied to the insect pyrokinin (PK)/pheromone biosynthesis activating neuropeptide (PBAN) family as a model, and led to the discovery of a potent linear lead antagonist and several highly potent, metabolically stable BBC antagonists, devoid of agonistic activity, which inhibited PBAN-mediated activities in moths in vivo. This review briefly summarizes our knowledge of insect Nps, describes the PK/PBAN Np family, presents the basic concepts behind the BBC-NBA approach, and introduces the advantages of this method for generation of Np agonists, antagonists and insecticide prototype molecules. © 2002 Wiley Periodicals, Inc.
Scientific Publication
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