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A novel day blindness in sheep: Epidemiological, behavioural, electrophysiological and histopathological studies
Year:
2010
Source of publication :
Veterinary Journal
Authors :
Gootwine, Elisha
;
.
Reicher, Shay
;
.
Volume :
185
Co-Authors:
Shamir, M.H., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Ofri, R., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Bor, A., Bor Clinic, Tel Aviv 67329, Israel
Brenner, O., The Weizmann Institute, Rehovot 76100, Israel
Reicher, S., Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel, A.R.O., The Volcani Center, Bet Dagan 50250, Israel
Obolensky, A., Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
Averbukh, E., Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
Banin, E., Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
Gootwine, E., A.R.O., The Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
130
To page:
137
(
Total pages:
8
)
Abstract:
Four genetically related Improved Awassi sheep flocks had sporadic births of lambs with congenital visual impairments that differed from other known forms of sheep blindness. Pedigree analysis suggested an autosomal recessive mode of inheritance. Behavioural studies of 4-month old affected lambs showed that their day vision (but not night vision) was impaired. Electrophysiological results at this age demonstrated diminished function of cones but not rods. Histopathological and immunohistochemical evaluation of affected retinas from 5-month old lambs revealed both red-green and blue cones, suggesting that the behavioural day blindness and reduced cone electroretinograms reflect cone dysfunction rather than severe cone photoreceptor loss. Awassi day blindness may be a form of achromatopsia. © 2009 Elsevier Ltd.
Note:
Related Files :
Animal
Animals
Female
Genetics
Male
metabolism
mutation
sheep
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More details
DOI :
10.1016/j.tvjl.2009.05.029
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
23740
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:02
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Scientific Publication
A novel day blindness in sheep: Epidemiological, behavioural, electrophysiological and histopathological studies
185
Shamir, M.H., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Ofri, R., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Bor, A., Bor Clinic, Tel Aviv 67329, Israel
Brenner, O., The Weizmann Institute, Rehovot 76100, Israel
Reicher, S., Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel, A.R.O., The Volcani Center, Bet Dagan 50250, Israel
Obolensky, A., Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
Averbukh, E., Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
Banin, E., Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
Gootwine, E., A.R.O., The Volcani Center, Bet Dagan 50250, Israel
A novel day blindness in sheep: Epidemiological, behavioural, electrophysiological and histopathological studies
Four genetically related Improved Awassi sheep flocks had sporadic births of lambs with congenital visual impairments that differed from other known forms of sheep blindness. Pedigree analysis suggested an autosomal recessive mode of inheritance. Behavioural studies of 4-month old affected lambs showed that their day vision (but not night vision) was impaired. Electrophysiological results at this age demonstrated diminished function of cones but not rods. Histopathological and immunohistochemical evaluation of affected retinas from 5-month old lambs revealed both red-green and blue cones, suggesting that the behavioural day blindness and reduced cone electroretinograms reflect cone dysfunction rather than severe cone photoreceptor loss. Awassi day blindness may be a form of achromatopsia. © 2009 Elsevier Ltd.
Scientific Publication
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