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אסיף מאגר המחקר החקלאי
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Calcium metabolism in birds: computer simulation of response to 1,25-dihydroxycholecalciferol.
Year:
1984
Source of publication :
The American journal of physiology
Authors :
Bär, Arie
;
.
Fishman, S. N.
;
.
Hurvitz, Shmuel (Animal science)
;
.
Talpaz, Hovav
;
.
Volume :
15
Co-Authors:
Hurwitz, S.
Fishman, S.
Bar, A.
Talpaz, H.
Facilitators :
From page:
684
To page:
687
(
Total pages:
4
)
Abstract:
A simulation model of calcium metabolism in the chick has been used to evaluate the response of the systems that regulate plasma calcium to a continuous input of 1,25-dihydroxycholecalciferol [1,25(OH)2D3] from the intestine. The results of simulation showed that the concentration of the vitamin D metabolite in the intestine increased during the first 24 h and thereafter decreased slightly due to suppression of endogenous hormone production. Metabolite accumulation was accompanied by an increase in calcium absorption, with a lag period of about 4 h. Most of the increase in absorbed calcium was excreted in the urine, with a lesser change in net bone calcium uptake. Plasma calcium increased with time, in proportion to the intake of the exogenous hormone. The validity of the predicted steady-state plasma calcium levels, and bone and kidney calcium flows, is discussed. The results of the simulation demonstrate the importance of the vitamin D-intestinal axis in regulation of plasma calcium.
Note:
Related Files :
Animal
article
Blood
calcitriol
calcium
chicken
Chickens
homeostasis
metabolism
Models, Biological
Show More
Related Content
More details
DOI :
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:

Pages: R684-R687

ID:
23994
Last updated date:
21/08/2022 07:45
Creation date:
17/04/2018 00:04
Scientific Publication
Calcium metabolism in birds: computer simulation of response to 1,25-dihydroxycholecalciferol.
15
Hurwitz, S.
Fishman, S.
Bar, A.
Talpaz, H.
Calcium metabolism in birds: computer simulation of response to 1,25-dihydroxycholecalciferol.
A simulation model of calcium metabolism in the chick has been used to evaluate the response of the systems that regulate plasma calcium to a continuous input of 1,25-dihydroxycholecalciferol [1,25(OH)2D3] from the intestine. The results of simulation showed that the concentration of the vitamin D metabolite in the intestine increased during the first 24 h and thereafter decreased slightly due to suppression of endogenous hormone production. Metabolite accumulation was accompanied by an increase in calcium absorption, with a lag period of about 4 h. Most of the increase in absorbed calcium was excreted in the urine, with a lesser change in net bone calcium uptake. Plasma calcium increased with time, in proportion to the intake of the exogenous hormone. The validity of the predicted steady-state plasma calcium levels, and bone and kidney calcium flows, is discussed. The results of the simulation demonstrate the importance of the vitamin D-intestinal axis in regulation of plasma calcium.
Scientific Publication
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