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Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task
Year:
1998
Source of publication :
Brain Research
Authors :
Meiri, Noam
;
.
Volume :
789
Co-Authors:
Meiri, N., Laboratory of Adaptive Systems, National Institutes of Health, Bethesda, MD 20892, United States, Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Rosenblum, K., Div. Neurophysiol. Neuropharmacology, Natl. Inst. of Med. Res., Mill Hill, London NW 71AA, United Kingdom, Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Facilitators :
From page:
48
To page:
55
(
Total pages:
8
)
Abstract:
Although protein synthesis inhibition has been shown to affect long- term memory in a wide variety of animal species, cases have been reported in which protein synthesis inhibition failed to affect memory consolidation [S. Wittstock, R. Menzel, Color learning and memory in honey bees are not affected by protein synthesis inhibition, Behav. Neural Biol., 62 (1994) 224- 229.]. Most findings argue that the critical time for protein synthesis is during or immediately after training. However, other reports show a second time window, hours after training, where protein synthesis inhibition can cause amnesia [F.M. Freeman, S.P.R. Rose, A.B. Scholey, Two time windows of anisomycin-induced amnesia for passive avoidance training in the day-old chick, Neurobiol. Learn. Mem., 63 (1995) 291-295.][G. Grecksch, H. Matthies, Two sensitive periods for the amnesic effect of anisomycin, Pharmacol. Biochem. Behav., 12 (1980) 663-665.]. In this study, we addressed two questions: (1) Is protein synthesis essential for spatial memory? and (2) At what injection time window(s) will protein synthesis inhibition cause spatial memory amnesia? We report that bilateral intraventricular microinjection of anisomycin (Ani) impairs consolidation of long-term memory, in the hippocampal-dependent Morris water maze spatial memory task. Memory was impaired in a dose-dependent manner without affecting short-term memory. Spatial memory was affected only if Ani was injected 20 min before performing the task and not in any other time window before or after the behavioral test. The inhibition did not affect pre-existing memories or the capability to memorize once the effect of the inhibition diminished.
Note:
Related Files :
animal experiment
Animals
Dose-Response Relationship, Drug
long term memory
Male
Space Perception
Water maze
Show More
Related Content
More details
DOI :
10.1016/S0006-8993(97)01528-X
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
24296
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:06
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Scientific Publication
Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task
789
Meiri, N., Laboratory of Adaptive Systems, National Institutes of Health, Bethesda, MD 20892, United States, Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Rosenblum, K., Div. Neurophysiol. Neuropharmacology, Natl. Inst. of Med. Res., Mill Hill, London NW 71AA, United Kingdom, Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task
Although protein synthesis inhibition has been shown to affect long- term memory in a wide variety of animal species, cases have been reported in which protein synthesis inhibition failed to affect memory consolidation [S. Wittstock, R. Menzel, Color learning and memory in honey bees are not affected by protein synthesis inhibition, Behav. Neural Biol., 62 (1994) 224- 229.]. Most findings argue that the critical time for protein synthesis is during or immediately after training. However, other reports show a second time window, hours after training, where protein synthesis inhibition can cause amnesia [F.M. Freeman, S.P.R. Rose, A.B. Scholey, Two time windows of anisomycin-induced amnesia for passive avoidance training in the day-old chick, Neurobiol. Learn. Mem., 63 (1995) 291-295.][G. Grecksch, H. Matthies, Two sensitive periods for the amnesic effect of anisomycin, Pharmacol. Biochem. Behav., 12 (1980) 663-665.]. In this study, we addressed two questions: (1) Is protein synthesis essential for spatial memory? and (2) At what injection time window(s) will protein synthesis inhibition cause spatial memory amnesia? We report that bilateral intraventricular microinjection of anisomycin (Ani) impairs consolidation of long-term memory, in the hippocampal-dependent Morris water maze spatial memory task. Memory was impaired in a dose-dependent manner without affecting short-term memory. Spatial memory was affected only if Ani was injected 20 min before performing the task and not in any other time window before or after the behavioral test. The inhibition did not affect pre-existing memories or the capability to memorize once the effect of the inhibition diminished.
Scientific Publication
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