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Kinetics of formation of neutralizing antibodies against vaccinia virus following re-vaccination
Year:
1999
Source of publication :
Vaccine
Authors :
Shoresh, Michal
;
.
Volume :
17
Co-Authors:
Stienlauf, S.
Shoresh, M.
Solomon, A.
Lublin-Tennenbaum, T., Department of Virology, Hebrew Univ.-Hadassah Med. Sch., P., Jerusalem 91120, Israel
Atsmon, Y.
Meirovich, Y.
Katz, E., Department of Virology, Hebrew Univ.-Hadassah Med. Sch., P., Jerusalem 91120, Israel
Facilitators :
From page:
201
To page:
204
(
Total pages:
4
)
Abstract:
Administration of vaccinia immune globulin (VIG), derived from vaccinated healthy adult volunteers, is the treatment-of-choice for patients suffering from severe complications following smallpox vaccination. The present study was aimed to determine the time interval after vaccination, at which the highest titer of neutralizing antibodies is obtained. Ninety-nine 18-year-old soldiers, immunized with vaccinia virus at birth, participated in the study, 87 of whom had detectable antibodies against vaccinia virus prior to re-vaccination. Their initial average neutralizing antibodies titer (NT50) was 27. Fourteen days after re-vaccination the titer reached 152 and then dropped to 136, 119, 110 and 87 at 21, 30, 45 and 60 d, respectively. The titers of vaccinia antibodies induced in vaccinees without detectable antibodies at the start of the study, were significantly lower and the titers observed after re-vaccination were: 62, 56, 66, 38 and 34, at 14, 21, 30, 45 and 60 d, respectively. In an additional study, 65 volunteers vaccinated at birth and again at the age of 8 years old were re-vaccinated. Fourteen days later their NT50 was higher than those vaccinated only at birth. It can be concluded that bleeding of vaccinees 14 d following re-vaccination is the preferable time for the preparation of VIG.
Note:
Related Files :
adult
Antibodies, Viral
drug induced disease
immunoglobulin
postvaccinal encephalitis
smallpox vaccine
Vaccination
Show More
Related Content
More details
DOI :
10.1016/S0264-410X(98)00197-2
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
24297
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:06
You may also be interested in
Scientific Publication
Kinetics of formation of neutralizing antibodies against vaccinia virus following re-vaccination
17
Stienlauf, S.
Shoresh, M.
Solomon, A.
Lublin-Tennenbaum, T., Department of Virology, Hebrew Univ.-Hadassah Med. Sch., P., Jerusalem 91120, Israel
Atsmon, Y.
Meirovich, Y.
Katz, E., Department of Virology, Hebrew Univ.-Hadassah Med. Sch., P., Jerusalem 91120, Israel
Kinetics of formation of neutralizing antibodies against vaccinia virus following re-vaccination
Administration of vaccinia immune globulin (VIG), derived from vaccinated healthy adult volunteers, is the treatment-of-choice for patients suffering from severe complications following smallpox vaccination. The present study was aimed to determine the time interval after vaccination, at which the highest titer of neutralizing antibodies is obtained. Ninety-nine 18-year-old soldiers, immunized with vaccinia virus at birth, participated in the study, 87 of whom had detectable antibodies against vaccinia virus prior to re-vaccination. Their initial average neutralizing antibodies titer (NT50) was 27. Fourteen days after re-vaccination the titer reached 152 and then dropped to 136, 119, 110 and 87 at 21, 30, 45 and 60 d, respectively. The titers of vaccinia antibodies induced in vaccinees without detectable antibodies at the start of the study, were significantly lower and the titers observed after re-vaccination were: 62, 56, 66, 38 and 34, at 14, 21, 30, 45 and 60 d, respectively. In an additional study, 65 volunteers vaccinated at birth and again at the age of 8 years old were re-vaccinated. Fourteen days later their NT50 was higher than those vaccinated only at birth. It can be concluded that bleeding of vaccinees 14 d following re-vaccination is the preferable time for the preparation of VIG.
Scientific Publication
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