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Expression of calcium-sensing receptor gene by avian parathyroid gland in vivo: Relationship to plasma calcium
Year:
2000
Authors :
Genina, Olga
;
.
Hurvitz, Shmuel (Animal science)
;
.
Lavelin, Irina
;
.
Pines, Mark
;
.
Yarden, Noa
;
.
Volume :
117
Co-Authors:
Yarden, N., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Lavelin, I., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Genina, O., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Diaz, R., Endocrine Hypertension Division, Department of Medicine, Brigham Women's Hosp. Harvard M., Boston, MA 02115, United States
Brown, E.M., Endocrine Hypertension Division, Department of Medicine, Brigham Women's Hosp. Harvard M., Boston, MA 02115, United States
Pines, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
173
To page:
181
(
Total pages:
9
)
Abstract:
Calcium-sensing receptor (CaR) gene expression and parathyroid hormone (PTH) content were evaluated in situ in chicken parathyroid glands (PG) in relation to changes in plasma calcium. The CaR gene is expressed by the parathyroid chief cells, the same cells that store and secrete PTH. An increase in plasma calcium, achieved by repletion of vitamin D-deficient chicks with a normal diet, by PTH injection, or during eggshell formation, increased the expression of the CaR gene. Low plasma calcium concentration in vitamin D-deficient chicks or in layers, before or after eggshell formation, was associated with decrease in CaR gene expression in the PG. The level of CaR gene expression was inversely correlated with the PTH content of the PG. The results of this study demonstrate for the first time that, in contrast to mammals, the CaR gene expression in the PG of the chicken is inversely associated with changes in plasma calcium. (C) 2000 Academic Press.
Note:
Related Files :
Animals
animal tissue
calcium blood level
Chickens
Egg Shell
Male
Parathyroid Glands
Receptors, Cell Surface
Show More
Related Content
More details
DOI :
10.1006/gcen.1999.7405
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
24463
Last updated date:
21/08/2022 07:45
Creation date:
17/04/2018 00:07
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Scientific Publication
Expression of calcium-sensing receptor gene by avian parathyroid gland in vivo: Relationship to plasma calcium
117
Yarden, N., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Lavelin, I., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Genina, O., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Diaz, R., Endocrine Hypertension Division, Department of Medicine, Brigham Women's Hosp. Harvard M., Boston, MA 02115, United States
Brown, E.M., Endocrine Hypertension Division, Department of Medicine, Brigham Women's Hosp. Harvard M., Boston, MA 02115, United States
Pines, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Expression of calcium-sensing receptor gene by avian parathyroid gland in vivo: Relationship to plasma calcium
Calcium-sensing receptor (CaR) gene expression and parathyroid hormone (PTH) content were evaluated in situ in chicken parathyroid glands (PG) in relation to changes in plasma calcium. The CaR gene is expressed by the parathyroid chief cells, the same cells that store and secrete PTH. An increase in plasma calcium, achieved by repletion of vitamin D-deficient chicks with a normal diet, by PTH injection, or during eggshell formation, increased the expression of the CaR gene. Low plasma calcium concentration in vitamin D-deficient chicks or in layers, before or after eggshell formation, was associated with decrease in CaR gene expression in the PG. The level of CaR gene expression was inversely correlated with the PTH content of the PG. The results of this study demonstrate for the first time that, in contrast to mammals, the CaR gene expression in the PG of the chicken is inversely associated with changes in plasma calcium. (C) 2000 Academic Press.
Scientific Publication
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