Biocatalysis and Biotransformation
Honig, H., Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16, A-8010, Graz, Austria
Shi, N., Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16, A-8010, Graz, Austria
Polanz, G., Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16, A-8010, Graz, Austria
The butyrates and acetates of heterocyclic alcohols like 3 - hydroxy tetrahydrofuran and - pyran, 3- and 4 - chromanol as well as the corresponding sulfur heterocycles were hydrolyzed using lipase from Candida rugosa (CRL) and from Pseudomonas cepacia, (PCL). Poor to excellent enantioselectivities were obtained depending on the structure of the substrates. An electrostatic amendment to the steric substrate model for PGL is proposed. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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Enzymatic resolutions of heterocyclic alcohols
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Honig, H., Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16, A-8010, Graz, Austria
Shi, N., Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16, A-8010, Graz, Austria
Polanz, G., Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16, A-8010, Graz, Austria
Enzymatic resolutions of heterocyclic alcohols
The butyrates and acetates of heterocyclic alcohols like 3 - hydroxy tetrahydrofuran and - pyran, 3- and 4 - chromanol as well as the corresponding sulfur heterocycles were hydrolyzed using lipase from Candida rugosa (CRL) and from Pseudomonas cepacia, (PCL). Poor to excellent enantioselectivities were obtained depending on the structure of the substrates. An electrostatic amendment to the steric substrate model for PGL is proposed. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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