Co-Authors:
Rosenthal, I., Department of Chemistry, Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, 84190, Israel
Riesz, P., A.R.O. Volcani Center, Department of Food Technology, P.O. Box 6, Bet Dagan, 50250, Israel
Faraggi, M., National Cancer Institute, National Institute of Health, Bethesda, MD, 20205, United States
Abstract:
The technique of pulse radiolysis has been utilized to study the reactions of some aza analogues of nucleic acid components with hydrated electrons and OH radicals. The absorption spectra of the transient free radical adducts which result from these reactions and their decay kinetics were determined. The 5-aza analogues gave similar results to those of pyrimidine bases. The 6-aza analogues also showed similar kinetics, however, transient spectra were different. The presence of the sugar moiety in these aza analogues changed the rate law of the OH adduct transient decay from second order to first order kinetics. This finding may have implications for the understanding of the radiation chemistry of DNA. © 1983 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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