Co-Authors:
Eastwood, F.W., Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel
Kirson, I., Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel
Lavie, D., Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel
Abraham, A., Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Abstract:
Three new withanolides have been isolated from hybrids obtained by crossing a chemotype of Withania somnifera received from South Africa and chemotype II originating in Israel. The compounds have been characterized as 4β,20α-dihydroxy-1-oxo-5β,6β-epoxy-20R,22R-witha-24-enolide, 20α-hydroxy-1,4-dioxo-5β,6β-epoxy-20R,22R-witha-2,24-dienolide, and 20α-hydroxy-1,4-dioxo-5β,6β-epoxy-20R,22R-witha-2-enolide. The major steroid of the plant is withanolide D, while the other known withanolides present are 4β,20α-dihydroxy-1-oxo-5β,6β-epoxy-20R,22R,24S,25R-witha-2-enolide and withaferin A. The structures assigned to the new compounds are based on spectral evidence, analysis of their fragmentation under electron impact, and on chemical correlation with known compounds. The formation of these withanolides in this new hybrid is discussed briefly. © 1980.
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הדגשת קישורים
חסימת אנימציה
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