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Annals of Nutrition and Metabolism
Bartov, I., Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX, United States, Department of Poultry Science, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan, Israel
Henderson, G.R., Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX, United States
Reiser, R., Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX, United States
The mechanism by which female rats maintain a higher level of serum cholesterol than males on cholesterol-containing diets was studied. Retention of neutral steroids and excretion of bile acids were significantly higher in females than in males. The composition of fecal bile acids was also sex-dependent. Lithocholic and α-muricholic acids were predominant in females and hyodeoxycholic in males. It was concluded that the sex differences in blood cholesterol levels are mainly due to the higher retention rate of neutral steroids by the females and not by their limited capacity to excrete bile acids. © 1974 by S. Karger AG, Basel.
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Sex differences in steroid retention and excretion in rats fed cholesterol
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Bartov, I., Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX, United States, Department of Poultry Science, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan, Israel
Henderson, G.R., Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX, United States
Reiser, R., Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX, United States
Sex differences in steroid retention and excretion in rats fed cholesterol
The mechanism by which female rats maintain a higher level of serum cholesterol than males on cholesterol-containing diets was studied. Retention of neutral steroids and excretion of bile acids were significantly higher in females than in males. The composition of fecal bile acids was also sex-dependent. Lithocholic and α-muricholic acids were predominant in females and hyodeoxycholic in males. It was concluded that the sex differences in blood cholesterol levels are mainly due to the higher retention rate of neutral steroids by the females and not by their limited capacity to excrete bile acids. © 1974 by S. Karger AG, Basel.
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