אסיף מאגר המחקר החקלאי

Linolenoyl Sorbitol and the Fragility of Hereditary Spherocytes

Year:

1973

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Authors :

Volume :

25

Co-Authors:

Livne, A., Division of Life Sciences, Negev Institute for Arid Zone Research, Israel, Department of Biology, University of the Negev, Beer Sheva, Israel
Aloni, B., Division of Life Sciences, Negev Institute for Arid Zone Research, Israel, Department of Biology, University of the Negev, Beer Sheva, Israel
Moses, S., Division of Life Sciences, Negev Institute for Arid Zone Research, Israel, Department of Biology, University of the Negev, Beer Sheva, Israel
Kuiper, P.J.C., Division of Life Sciences, Negev Institute for Arid Zone Research, Israel, Department of Biology, University of the Negev, Beer Sheva, Israel

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Abstract:

Summary. Linolenoyl sorbitol decreased uniformly the osmotic fragility of normal human red cells. When added to red cells of patients with hereditary spherocytosis (HS), the synthetic lipid afforded the most fragile cells the greatest shift in osmotic stability. The greater the osmotic fragility of red cells from different patients, the greater the protective effect afforded by the added lipid. Linolenoyl sorbitol fully reversed the increased fragility of vinblastin‐treated red cells. The results indicate a causal relationship between the lipid composition and the increased fragility of red cells in hereditary spherocytosis. Copyright © 1973, Wiley Blackwell. All rights reserved

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