Expression of the rat myosin light-chain 2 gene in transgenic mice: stage specificity, developmental regulation, and interrelation with the endogenous gene.

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Expression of the rat myosin light-chain 2 gene in transgenic mice: stage specificity, developmental regulation, and interrelation with the endogenous gene.

Year: 

1988

Source of publication :

Molecular and Cellular Biology

Authors :

Dekel, Itzhak

;

Shani, Moshe

;

Yoffe, Olla

.

Volume :

Co-Authors: 

Shani, M., Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Dekel, I., Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Yoffe, O., Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

From page: 

1006

To page: 

1009

(

Total pages: 

4

)

Link :

Expression of the rat myosin light-chain 2 gene in transgenic mice: stage specificity, developmental regulation, and interrelation with the endogenous gene.

Abstract: 

The expression of the rat skeletal myosin light-chain 2 gene in two transgenic strains was tissue specific and stage specific. However, the temporal regulation during development of the transgene was different from that of the endogenous gene. Surprisingly, in one strain, the expression of the transgene was associated with a significant down-regulation of the endogenous gene. The possible mechanisms to account for the suppression of the endogenous gene and the potential implications of this suppression are discussed.