Co-Authors:
Gidoni, D., Department of Biochemistry, University of California, Berkeley, CA 94720, United States
Kadonaga, J.T., Department of Biochemistry, University of California, Berkeley, CA 94720, United States
Barrera-Saldana, H., Department of Biochemistry, University of California, Berkeley, CA 94720, United States
Takahashi, K.
Chambon, P.
Tjian, R.
Abstract:
The 21-base pair repeat elements of the SV40 promoter contain six tandem copies of the GGGCGG hexanucleotide (GC-box), each of which can bind, with varying affinity, to the cellular transcription factor, Sp1. In vitro SV40 early RNA synthesis is mediated by interaction of Sp1 with GC-boxes I, II, and III, whereas transcription in the late direction is mediated by binding to GC-boxes III, V, and VI.
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