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Kol, R., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel
Ben-Hur, E., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel
Riklis, E., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel
Marko, R., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel
Rosenthal, I., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel, Department of Food Science, ARO, The Volcani Center, PO Box 6, Bet-Dagan, Israel
Photosensitization of peripheral human lymphocytes by aluminium phthalocyanine tetrasulphonate (AlPCS) was studied, by using inhibition of mitogenic stimulation as an end-point. AlPCS was found to be an efficient photosensitizer for the various subpopulations of lymphocytes. However, there are large variations in the responses of lymphocytes from various donors. DNA and RNA syntheses were inhibited by AlPCS photosensitization in proliferating lymphocytes to a similar extent. Protein synthesis, however, was considerably more sensitive. Delaying the addition of AlPCS to 5 h after the stimulation by phytohaemagglutinin (PHA) reduced its photosensitizing activity compared to cells stimulated promptly after treatment. When the stimulation with PHA was performed 4 h after light exposure, the effect was essentially the same as when PHA was added immediately after irradiation. This latter result suggests that no repair of potentially lethal damage occurred during the 4-h interval. © 1986 Baillière Tindall.
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Photosensitized inhibition of mitogenic stimulation of human lymphocytes by aluminium phthalocyanine tetrasulphonate
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Kol, R., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel
Ben-Hur, E., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel
Riklis, E., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel
Marko, R., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel
Rosenthal, I., Department of Radiobiology, Nuclear Research Center-Negev, PO Box 9001, Beer-Sheva, Israel, Department of Food Science, ARO, The Volcani Center, PO Box 6, Bet-Dagan, Israel
Photosensitized inhibition of mitogenic stimulation of human lymphocytes by aluminium phthalocyanine tetrasulphonate
Photosensitization of peripheral human lymphocytes by aluminium phthalocyanine tetrasulphonate (AlPCS) was studied, by using inhibition of mitogenic stimulation as an end-point. AlPCS was found to be an efficient photosensitizer for the various subpopulations of lymphocytes. However, there are large variations in the responses of lymphocytes from various donors. DNA and RNA syntheses were inhibited by AlPCS photosensitization in proliferating lymphocytes to a similar extent. Protein synthesis, however, was considerably more sensitive. Delaying the addition of AlPCS to 5 h after the stimulation by phytohaemagglutinin (PHA) reduced its photosensitizing activity compared to cells stimulated promptly after treatment. When the stimulation with PHA was performed 4 h after light exposure, the effect was essentially the same as when PHA was added immediately after irradiation. This latter result suggests that no repair of potentially lethal damage occurred during the 4-h interval. © 1986 Baillière Tindall.
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