אסיף מאגר המחקר החקלאי

Syntheses of polymeric vesicles containing partial structures of N-acetyl-muramyl-dipeptide (MDP)

Year:

1990

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Volume :

53

Co-Authors:

Hönig, H., Institute of Organic Chemistry, Graz University of Technology, Graz, Stremayrgasse 16, A-8010 Graz, Austria
Zenk, R., Institute of Organic Chemistry, Graz University of Technology, Graz, Stremayrgasse 16, A-8010 Graz, Austria

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Abstract:

The syntheses of 11-methacroylaminoundecanoyl-l-alanyl-d-isoglutamine (3) and 2-[2-(11-methacroylaminoundecanoyl)-aminoethoxy]propanoyl-l-alanyl-d-isoglutamine (13) are described. Each of these monomers has been copolymerized with 11-methacroyloxyundecyltrimethylammonium bromide (16), yielding polymeric vesicles that contain partial structures of N-acetylmuramyl dipeptide (MDP). All products have been characterized by 1H- and 13C-NMR spectroscopy and the polymeric vesicles have been studied by electron microscopy. The potential use of these structures as immunostimulating products is discussed. © 1990.

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