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Use of 1 alpha-hydroxyvitamin D3 in the prevention of bovine parturient paresis. IX. Early and late effects of a single injection.
Year:
1987
Source of publication :
Journal of Dairy Science
Authors :
Bär, Arie
;
.
Perlman, Rivka
;
.
Volume :
70
Co-Authors:

Sachs, M., Haklait, Veterinary Clinical Services, Netanya, Israel.
Perlman, R., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel.
Bar, A., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel.

Facilitators :
From page:
1671
To page:
1675
(
Total pages:
5
)
Abstract:
Israeli Friesian cows in the third or later lactation were injected intramuscularly (serratus muscle of the neck) with 1 alpha-hydroxyvitamin D3 in propylene glycol in order to compare the short-term and long-term effects of the drug. Following injection of 700 micrograms 1 alpha-hydroxyvitamin D3, the D-derivative appeared in the plasma after 12 h and reached a peak 24 h after injection. Plasma 1,25-dihydroxyvitamin D increased as early as 6 h and peaked at 24 h. Plasma calcium increased after 6 h and peaked 4 to 5 d after the injection. The administration of a single dose of 350 micrograms 1 alpha-hydroxyvitamin D3 at 7 to 8 d before calving did not prevent periparturient hypocalcaemia observed in the uninjected control cows. A single injection of 700 micrograms 1 alpha-hydroxyvitamin D3 7 to 8 d before parturition prevented hypocalcemia at calving. There were no significant differences in plasma calcium 4 to 21 d after calving between the injected and control cows nor were there any cases of delayed postparturient hypocalcemia or milk fever. Results suggest that 700 micrograms 1 alpha-hydroxyvitamin D3 prolonged the calcemic effect of the drug and prevented hypocalcemia at parturition, even if administered 6 to 8 d before calving.
Note:
Related Files :
1-hydroxycholecalciferol
alfacalcidol
Animal
animal disease
Blood
calcitriol
cattle
Female
parturient paresis
pregnancy
Show More
Related Content
More details
DOI :
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
26212
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:21
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Scientific Publication
Use of 1 alpha-hydroxyvitamin D3 in the prevention of bovine parturient paresis. IX. Early and late effects of a single injection.
70

Sachs, M., Haklait, Veterinary Clinical Services, Netanya, Israel.
Perlman, R., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel.
Bar, A., Institute of Animal Science, Agricultural Research Organization, Vocani Center, Bet Dagan, Israel.

Use of 1 alpha-hydroxyvitamin D3 in the prevention of bovine parturient paresis. IX. Early and late effects of a single injection.
Israeli Friesian cows in the third or later lactation were injected intramuscularly (serratus muscle of the neck) with 1 alpha-hydroxyvitamin D3 in propylene glycol in order to compare the short-term and long-term effects of the drug. Following injection of 700 micrograms 1 alpha-hydroxyvitamin D3, the D-derivative appeared in the plasma after 12 h and reached a peak 24 h after injection. Plasma 1,25-dihydroxyvitamin D increased as early as 6 h and peaked at 24 h. Plasma calcium increased after 6 h and peaked 4 to 5 d after the injection. The administration of a single dose of 350 micrograms 1 alpha-hydroxyvitamin D3 at 7 to 8 d before calving did not prevent periparturient hypocalcaemia observed in the uninjected control cows. A single injection of 700 micrograms 1 alpha-hydroxyvitamin D3 7 to 8 d before parturition prevented hypocalcemia at calving. There were no significant differences in plasma calcium 4 to 21 d after calving between the injected and control cows nor were there any cases of delayed postparturient hypocalcemia or milk fever. Results suggest that 700 micrograms 1 alpha-hydroxyvitamin D3 prolonged the calcemic effect of the drug and prevented hypocalcemia at parturition, even if administered 6 to 8 d before calving.
Scientific Publication
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